Hao Yang, Zhang Feifan, Ma Yan, Luo Yage, Zhang Yongyong, Yang Ning, Liu Man, Liu Hongjian, Li Jitian
Laboratory of Molecular Biology, Henan Luoyang Orthopedic Hospital (Henan Provincial Orthopedic Hospital), Zhengzhou, China.
Henan University of Chinese Medicine, Zhengzhou, China.
Front Oncol. 2023 Jun 19;13:1188357. doi: 10.3389/fonc.2023.1188357. eCollection 2023.
The clinical manifestations of bone metastases are diversified while many sites remain asymptomatic at early stage. As the early diagnosis method is not perfect and the early symptoms of tumor bone metastasis are not typical, bone metastasis is not easy to be detected. Therefore, the search for bone metastasis-related markers is effective for timely detection of tumor bone metastases and the development of drugs to inhibit bone metastases. As a result, bone metastases can only be diagnosed when symptoms are found, increasing the risk of developing skeletal-related event (SREs), which significantly impairs the patient's quality of life. Therefore, the early diagnosis of bone metastases is of great importance for the treatment and prognosis of cancer patients. Changes of bone metabolism indexes appear earlier in bone metastases, but the traditional biochemical indexes of bone metabolism lack of specificity and could be interfered by many factors, which limits their application in the study of bone metastases. Some new biomarkers of bone metastases have good diagnostic value, such as proteins, ncRNAs, circulating tumor cells (CTCs). Therefore, this study mainly reviewed the initial diagnostic biomarkers of bone metastases which were expected to provide references for the early detection of bone metastases.
骨转移的临床表现多种多样，许多部位在早期仍无症状。由于早期诊断方法不完善，且肿瘤骨转移的早期症状不典型，骨转移不易被发现。因此，寻找骨转移相关标志物对于及时发现肿瘤骨转移以及开发抑制骨转移的药物具有重要意义。结果，骨转移往往只有在出现症状时才能被诊断出来，这增加了发生骨相关事件（SREs）的风险，严重损害了患者的生活质量。因此，骨转移的早期诊断对于癌症患者的治疗和预后至关重要。骨代谢指标的变化在骨转移中出现得更早，但传统的骨代谢生化指标缺乏特异性，且易受多种因素干扰，这限制了它们在骨转移研究中的应用。一些新的骨转移生物标志物具有良好的诊断价值，如蛋白质、非编码RNA、循环肿瘤细胞（CTCs）。因此，本研究主要综述了骨转移的初始诊断生物标志物，以期为骨转移的早期检测提供参考。
