Omrani Hamidreza, Bahremand Mostafa, Keshavarzi Fatemeh, Solouki Leila, Zereshki Ehsan
Cardiovascular Research Center, Health Institute, Imam-Ali Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Student Research Committee, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
J Educ Health Promot. 2023 May 31;12:171. doi: 10.4103/jehp.jehp_845_22. eCollection 2023.
High blood pressure (BP) is considered as the most important risk factor for cardiovascular disease (CVD). The main aim of this study was to investigate the effect of polypill on BP by reviewing clinical trial studies.
In this systematic review study, online databases such as PubMed, Scopus, and Web of Science databases with no limited time were systematically searched until July 10, 2020. Clinical trial studies published in English that examined the effect of polypill on BP were included. BP was the main outcome investigated.
Eleven original articles with a population of 17,042 people were reviewed. The polypill drugs studied in this study had different compounds. Compared to conventional care, treatment with polypill compounds has a positive and significant effect on lowering BP ( < 0.05).
Our finding confirmed that polypills could reduce BP in patients. It seems that changing routine care and replacing it with a polypill strategy could facilitate the achievement of BP control goals.
高血压被认为是心血管疾病（CVD）最重要的危险因素。本研究的主要目的是通过回顾临床试验研究来调查复方制剂对血压的影响。
在这项系统评价研究中，对PubMed、Scopus和Web of Science等在线数据库进行了不限时间的系统检索，直至2020年7月10日。纳入以英文发表的、研究复方制剂对血压影响的临床试验研究。血压是主要研究结局。
对11篇涉及17042人的原始文章进行了综述。本研究中所研究的复方制剂药物有不同的成分。与传统治疗相比，使用复方制剂成分进行治疗对降低血压有积极且显著的效果（<0.05）。
我们的研究结果证实，复方制剂可降低患者血压。似乎改变常规治疗并采用复方制剂策略可以促进血压控制目标的实现。
