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评估美国有关患者年龄和提供生育治疗政策的调查。

Survey assessing policies regarding patient age and provision of fertility treatment in the United States.

机构信息

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Duke University Medical Center, 2301 Erwin Rd, Durham, NC, 27710, USA.

出版信息

J Assist Reprod Genet. 2023 Sep;40(9):2117-2127. doi: 10.1007/s10815-023-02877-x. Epub 2023 Jul 5.

Abstract

PURPOSE

To determine what policies exist regarding age and provision of fertility treatment in United States fertility clinics.

METHODS

Medical directors of the Society for Assisted Reproductive Technology (SART) member clinics were surveyed regarding clinic demographics and current policies pertaining to age and provision of fertility treatment. Univariate comparisons were performed using Chi-square and Fisher exact tests as appropriate, with significance set at P ≤ 0.05.

RESULTS

Of the 366 clinics surveyed, 18.9% (69/366) responded. A majority of clinics who responded 88.4% (61/69) reported having a policy regarding patient age and provision of fertility treatment. Responding clinics with an age policy did not differ from those without a policy on the basis of geographical location, (p = 0.5), insurance mandate status (p = 0.9), practice type (p = 0.4), or annual number of ART cycles (p = 0.7). Of all clinics who responded, 73.9% (51/69) had a maximum maternal age for autologous IVF, with a median of 45 years (range 42-54). Similarly, 79.7% (55/69) of responding clinics had a maximum maternal age for donor oocyte IVF, with a median of 52 years (range 48-56). Slightly under half, 43.4% (30/69) of responding clinics had a maximum maternal age for fertility treatment other than IVF (including ovulation induction or ovarian stimulation with or without IUI) with a median of 46 years (range 42-55). Of note, only 4.3% (3/69) of responding clinics had a policy with respect to maximum paternal age, with a median of 55 years (range 55-70). The most commonly cited reasons for having an age-limit policy were maternal risks of pregnancy, lower ART success rates, fetal/neonatal risks, and concerns about patients' ability to parent at an older age. More than half 56.5% (39/69) of responding clinics reported making exceptions to these policies, most commonly for patients who have pre-existing embryos. The majority of medical directors who responded to the survey believed there should be an ASRM guideline regarding maximum maternal age for autologous IVF 71% (49/69), donor oocyte IVF 78% (54/69) and other fertility treatments 62% (43/69).

CONCLUSIONS

Most fertility clinics who responded to this national survey reported having a policy regarding maternal age (but not paternal age) and provision of fertility treatment. Policies were based on risk of maternal/fetal complications, lower success rates at older age, and concerns about patients' ability to parent at an older age. The majority of medical directors of responding clinics believed there should be an ASRM guideline regarding age and provision of fertility treatment.

摘要

目的

确定美国生育诊所中有关年龄和提供生育治疗的政策。

方法

对辅助生殖技术协会(SART)成员诊所的医学主任进行了调查,以了解诊所的人口统计学特征和当前与年龄及提供生育治疗相关的政策。使用卡方检验和 Fisher 确切检验进行单变量比较,以 P≤0.05 为显著性水平。

结果

在接受调查的 366 家诊所中,有 18.9%(69/366)做出了回应。大多数做出回应的诊所(88.4%,61/69)报告说有关于患者年龄和提供生育治疗的政策。有年龄政策的诊所与没有年龄政策的诊所之间在地理位置(p=0.5)、保险授权状况(p=0.9)、实践类型(p=0.4)或每年接受的 ART 周期数(p=0.7)方面没有差异。在所有做出回应的诊所中,有 73.9%(51/69)对自体 IVF 设定了最大产妇年龄,中位数为 45 岁(范围 42-54)。同样,有 79.7%(55/69)的诊所对供卵 IVF 设定了最大产妇年龄,中位数为 52 岁(范围 48-56)。略低于一半,有 43.4%(30/69)的做出回应的诊所对除 IVF 以外的生育治疗设定了最大产妇年龄,中位数为 46 岁(范围 42-55)。值得注意的是,只有 4.3%(3/69)的做出回应的诊所对最大父龄有政策规定,中位数为 55 岁(范围 55-70)。设定年龄限制政策的最常见原因是妊娠的母婴风险、较低的 ART 成功率、胎儿/新生儿风险以及对患者在较晚年龄生育能力的担忧。超过一半的做出回应的诊所(56.5%,39/69)报告对这些政策做出了例外,最常见的情况是对有预先存在胚胎的患者。大多数回应调查的医学主任认为,应该有一个关于最大产妇年龄的 ASRM 指南,适用于自体 IVF(71%,49/69)、供卵 IVF(78%,54/69)和其他生育治疗(62%,43/69)。

结论

大多数对这项全国性调查做出回应的生育诊所都报告了有关产妇年龄(而非父龄)和生育治疗提供的政策。这些政策是基于母婴并发症风险、高龄时成功率较低以及对患者在高龄时生育能力的担忧。大多数回应诊所的医学主任认为,应该有一个关于年龄和生育治疗提供的 ASRM 指南。

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