Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai 200030, China.
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai 200030, China; The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, China.
J Psychosom Res. 2023 Sep;172:111432. doi: 10.1016/j.jpsychores.2023.111432. Epub 2023 Jun 28.
Little is known about the role of childhood experiences in the development of obsessive-compulsive disorder (OCD). However, the influence of childhood experiences on personality, behavior, and perceived stress may vary between OCD patients and healthy individuals. The objective of this study was to use network analysis to explore the relationship between childhood trauma, personality, perceived stress, and symptom dimensions, thus finding the difference between patients' and healthy people's network.
488 patients with OCD and 210 healthy volunteers were recruited. All of them were assessed with the Obsessive-Compulsive Inventory - Revised (OCI-R), the Perceived Stress Scale-10, the NEO Five-Factor Inventory and the Early Trauma Inventory Self-Report Short Form. Network analysis was conducted and the centrality indices were calculated. Network comparison test was performed.
In patients' network, the Obsession and the Ordering behavior were the most important nodes among the OCI-R. The perceived stress showed the strongest strength centrality of all nodes and positive correlation with the Obsession and Neuroticism. Network comparison test results indicated a statistically significant difference between network structure, and post-hoc analysis found five edges significantly differed between patients and healthy controls, mainly on Obsession and Washing behaviors.
Emotional abuse was considered significant in both networks due to its higher strength centrality. Meanwhile, perceived stress was found to be more significant in the patient network and exhibited stronger associations with obsession. The obsessive thoughts and washing behavior were different among patients and healthy controls, which brought new understanding to the pathopsychological mechanisms of OCD.
关于童年经历在强迫症（OCD）发展中的作用知之甚少。然而，童年经历对人格、行为和感知压力的影响在 OCD 患者和健康个体之间可能有所不同。本研究的目的是使用网络分析来探讨童年创伤、人格、感知压力和症状维度之间的关系，从而找到患者和健康人群网络之间的差异。
招募了 488 名 OCD 患者和 210 名健康志愿者。所有参与者均接受了强迫症清单修订版（OCI-R）、感知压力量表-10、NEO 五因素人格量表和早期创伤量表自我报告简短形式的评估。进行了网络分析并计算了中心性指数。进行了网络比较测试。
在患者的网络中，强迫观念和秩序行为是 OCI-R 中最重要的节点。感知压力显示出所有节点中最强的强度中心性，与强迫观念和神经质呈正相关。网络比较测试结果表明网络结构存在统计学差异，事后分析发现患者和健康对照组之间有五条边缘存在显著差异，主要是在强迫观念和洗涤行为上。
由于其较高的强度中心性，情感虐待被认为在两个网络中都很重要。同时，感知压力在患者网络中更为显著，与强迫观念的关联更强。患者和健康对照组之间的强迫思维和洗涤行为存在差异，这为 OCD 的病理心理机制提供了新的认识。
