Department of Cardiovascular Pharmacology, Amity Institute of Pharmacy, Amity University, Gurugram, Haryana 122413, India.
Department of Cardiovascular Pharmacology, Amity Institute of Pharmacy, Amity University, Gurugram, Haryana 122413, India.
Drug Discov Today. 2023 Oct;28(10):103695. doi: 10.1016/j.drudis.2023.103695. Epub 2023 Jul 3.
This report focuses on small non-coding RNA molecules (miRNAs), which have emerged as potential biomarkers with variable diagnostic values and false-positives in different conditions that limit their clinical preference. Current investigations focus on small non-coding RNA molecules (miRNAs), which have emerged as potential biomarkers with variable diagnostic values and false-positives in different conditions that limit their clinical preference. We thoroughly scrutinize the leading pathology of myocardial infarction and contemporary alterations in miRNAs for their specificity, stability and significant prognostic value at the early stage of acute myocardial infarction (AMI). Based on secondary data analysis, we explore common biomarkers and further investigate included miRNA biomarkers for their specificity, stability and area under the curve (AUC) values. We conclude that a group of novel biomarkers, including miRNA-1, miRNA-208a/b and miRNA-499, could help predict the emergence of AMI at an early stage.
本报告重点介绍了小非编码 RNA 分子（miRNAs），它们作为潜在的生物标志物，在不同情况下具有不同的诊断价值和假阳性率，这限制了它们的临床应用。目前的研究集中在小非编码 RNA 分子（miRNAs）上，它们作为潜在的生物标志物，在不同情况下具有不同的诊断价值和假阳性率，这限制了它们的临床应用。我们深入研究了心肌梗死的主要病理和 miRNA 在急性心肌梗死（AMI）早期的特异性、稳定性和显著预后价值方面的最新变化。基于二次数据分析，我们探讨了常见的生物标志物，并进一步研究了纳入的 miRNA 生物标志物的特异性、稳定性和曲线下面积（AUC）值。我们得出结论，一组新的生物标志物，包括 miRNA-1、miRNA-208a/b 和 miRNA-499，可以帮助预测 AMI 的早期发生。
