Xu Lixin, Lin Jianfeng, Xia Jianke, Chen Deng, He Guohan
Department of Ultrasound, Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou People's Hospital, Third Affiliated Hospital of Shanghai University, Wenzhou City, Zhejiang Province, 325000, China.
Department of Cardiology, Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou People's Hospital, Third Affiliated Hospital of Shanghai University, No. 299, Gu'an Road, Ouhai District, Wenzhou, Zhejiang, 325000, China.
J Cardiothorac Surg. 2025 Jan 7;20(1):42. doi: 10.1186/s13019-024-03201-z.
Diagnosis and prognostic evaluation of acute myocardial infarction (AMI) are crucial for patients.
The clinical significance of serum miR-199a-5p combined with echocardiography in AMI was investigated to provide some reference for clinical treatment.
The study subjects were 90 AMI patients and 50 acute chest pain patients (control). All patients were examined by echocardiography and recorded LVEDV, LVESV, and LVEF. RT-qPCR was performed to detect the serum miR-199a-5p level. Pearson analysis was used to analyze the correlation of miR-199a-5p with LVEF and cTnI. The diagnostic value of miR-199a-5p combined with LVEDV, LVESV, and LVEF was assessed by the ROC curve. The occurrence of major adverse cardiovascular events (MACE) was recorded to analyze the prognostic value of miR-199a-5p by the Kaplan-Meier curve and Cox regression.
Serum miR-199a-5p was elevated in AMI, positively correlated with cTnI and negatively correlated with LVEF. The combination of miR-199a-5p with LVEDV, LVESV, and LVEF enhanced the sensitivity and specificity for the diagnosis of AMI. Patients with high miR-199a-5p expression were more likely to develop MACE. The combination of miR-199a-5p with LVEF improved the prediction of MACE.
The combination of miR-199a-5p with echocardiography improved the diagnostic efficiency of AMI and provided prognostic information.
急性心肌梗死（AMI）的诊断和预后评估对患者至关重要。
探讨血清miR-199a-5p联合超声心动图在AMI中的临床意义，为临床治疗提供参考。
研究对象为90例AMI患者和50例急性胸痛患者（对照组）。所有患者均接受超声心动图检查，记录左心室舒张末期容积（LVEDV）、左心室收缩末期容积（LVESV）和左心室射血分数（LVEF）。采用逆转录定量聚合酶链反应（RT-qPCR）检测血清miR-199a-5p水平。采用Pearson分析miR-199a-5p与LVEF及肌钙蛋白I（cTnI）的相关性。通过ROC曲线评估miR-199a-5p联合LVEDV、LVESV和LVEF的诊断价值。记录主要不良心血管事件（MACE）的发生情况，通过Kaplan-Meier曲线和Cox回归分析miR-199a-5p的预后价值。
AMI患者血清miR-199a-5p升高，与cTnI呈正相关，与LVEF呈负相关。miR-199a-5p联合LVEDV、LVESV和LVEF可提高AMI诊断的敏感性和特异性。miR-199a-5p表达高的患者发生MACE的可能性更大。miR-199a-5p与LVEF联合可改善MACE的预测。
miR-199a-5p联合超声心动图提高了AMI的诊断效率，并提供了预后信息。
