Agarwal Tarun, Chiesa Irene, Costantini Marco, Lopamarda Anna, Tirelli Maria Celeste, Borra Om Prakash, Varshapally Subhash Venkata Sai, Kumar Yanamadala Ashwin Vijay, Koteswara Reddy G, De Maria Carmelo, Zhang Lijie Grace, Maiti Tapas Kumar
Department of Bio-Technology, Koneru Lakshmaiah Education Foundation, Vaddeswaram, AP, India.
Research Center "E. Piaggio", Department of Information Engineering, University of Pisa, Largo Lucio Lazzarino 1, 56122 Pisa, Italy.
Int J Biol Macromol. 2023 Aug 15;246:125669. doi: 10.1016/j.ijbiomac.2023.125669. Epub 2023 Jul 3.
Tissue engineering research has undergone to a revolutionary improvement, thanks to technological advancements, such as the introduction of bioprinting technologies. The ability to develop suitable customized biomaterial inks/bioinks, with excellent printability and ability to promote cell proliferation and function, has a deep impact on such improvements. In this context, printing inks based on chitosan and its derivatives have been instrumental. Thus, the current review aims at providing a comprehensive overview on chitosan-based materials as suitable inks for 3D/4D (bio)printing and their applicability in creating advanced drug delivery platforms and tissue engineered constructs. Furthermore, relevant strategies to improve the mechanical and biological performances of this biomaterial are also highlighted.
由于技术进步，如生物打印技术的引入，组织工程研究取得了革命性的进展。开发具有优异可打印性以及促进细胞增殖和功能能力的合适定制生物材料墨水/生物墨水的能力，对这种进展产生了深远影响。在这种背景下，基于壳聚糖及其衍生物的打印墨水发挥了重要作用。因此，本综述旨在全面概述基于壳聚糖的材料作为适用于3D/4D（生物）打印的墨水及其在创建先进药物递送平台和组织工程构建体中的适用性。此外，还强调了改善这种生物材料的机械和生物学性能的相关策略。
