Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Int J Pharm. 2023 Jul 25;642:123204. doi: 10.1016/j.ijpharm.2023.123204. Epub 2023 Jul 3.
This study presents a meta-analysis that compiles information collected from several studies aiming to prove, by evidence, that nanocarriers out-perform conventional formulations in augmenting the bioavailability of ocular topically administered drugs. Data was further categorized into two subgroups; polymeric-based nanocarriers versus their lipid-based counterparts, as well as, naturally-driven carriers versus synthetically-fabricated ones. After normalization, the pharmacokinetic factor, area under the curve (AUC), was denoted as the "effect" in the conducted study, and the corresponding Forest plots were obtained. Our meta-analysis study confirmed the absorption enhancement effect of loading drugs into nanocarriers as compared to conventional topical ocular dosage forms. Interestingly, no significant differences were recorded between the polymeric and lipidic nanocarriers included in the study, while naturally-driven nanoplatforms were proven superior to the synthetic alternatives.
本研究进行了荟萃分析，综合了多项旨在通过证据证明纳米载体在提高眼部局部给药药物生物利用度方面优于传统制剂的研究信息。数据进一步分为两组；基于聚合物的纳米载体与基于脂质的纳米载体，以及天然驱动的载体与合成制造的载体。归一化后，药代动力学因素，曲线下面积（AUC），在进行的研究中被表示为“效应”，并获得了相应的森林图。我们的荟萃分析研究证实了将药物载入纳米载体与传统眼部局部剂型相比的吸收增强效果。有趣的是，研究中包含的聚合物和脂质纳米载体之间没有记录到显著差异，而天然驱动的纳米平台被证明优于合成替代品。
