Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, African Union Organization Street, Abbassia, Cairo, Egypt.
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, African Union Organization Street, Abbassia, Cairo, Egypt.
Int J Pharm. 2021 Dec 15;610:121268. doi: 10.1016/j.ijpharm.2021.121268. Epub 2021 Nov 5.
Cancer is the prime cause of mortality throughout the world. Although the conventional chemotherapeutic agents damage the cancerous cells, they exert prominent injury to the normal cells owing to their lack of specificity. With advances in science, many research studies have been established to boost the cytotoxic effect of the chemotherapeutic agents via innovating novel nano-formulations having different variables. In the current meta-analysis study, combined data from different research articles were gathered for the evidence-based proof of the superiority of drug loaded nanocarriers over their corresponding conventional solutions in boosting the cytotoxic effect of chemotherapy in terms of IC50 values. The meta-analysis was subdivided into three subgroups; nanoparticles versus nanofibers, surface functionalized nanocarriers versus naked ones, and protein versus non-protein-based platforms. The different subgroups interestingly showed distinct scoring outcome data paving the road for cytotoxicity enhancement of the anti-cancer drugs in an evidence-based manner.
癌症是全球主要的死亡原因。尽管传统的化疗药物会损伤癌细胞，但由于缺乏特异性，它们会对正常细胞造成明显的损伤。随着科学的进步，已经进行了许多研究来通过创新具有不同变量的新型纳米制剂来提高化疗药物的细胞毒性作用。在当前的荟萃分析研究中，从不同研究文章中收集了合并数据，以基于 IC50 值证明载药纳米载体优于其相应的常规溶液，从而提高化疗的细胞毒性作用。荟萃分析分为三个亚组；纳米颗粒与纳米纤维、表面功能化纳米载体与裸纳米载体、以及蛋白与非蛋白基平台。不同的亚组有趣地显示出不同的评分结果数据，为以循证方式增强抗癌药物的细胞毒性铺平了道路。
