Chen Yinfei, Wen Weiheng, Mai Zhiliang, Wang Ming, Chen Hong, Sun Jia
Department of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Department of Digestive Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
J Diabetes. 2023 Oct;15(10):808-816. doi: 10.1111/1753-0407.13435. Epub 2023 Jul 5.
There is a lack of research regarding the relationship between creatinine to cystatin C to waist circumference ratio (CCR/WC ratios) and the development of type 2 diabetes mellitus (T2DM). We aimed to evaluate the association between CCR/WC ratios and incident T2DM in Chinese adults.
This prospective study was from the China Health and Retirement Longitudinal Study (2011, 2013, 2015, and 2018). The participants were divided into three groups by tertiaries of the CCR/WC ratios. Cox proportional-hazards models were used to identify the relationship between CCR/WC and T2DM.
Overall, 5938 participants were included for analysis, 766 of whom developed T2DM between 2011 and 2018. Risk of incident T2DM was decreased with tertiaries 2, 3 versus tertiary 1 of the CCR/WC index (adjusted hazard ratio [HR] 0.772 [95% confidence interval 0.647-0.921] and 0.724 [0.596-0.880], p for trend = .001 across tertiaries of the CCR/WC index). The results were consistent excluding participants with T2DM in the first 2 years.
This study demonstrated that CCR/WC was negatively correlated with the risk of T2DM in Chinese adults. Early detection is necessary to control the development of T2DM in Chinese with low CCR/WC levels.
关于肌酐与胱抑素C与腰围比值（CCR/WC比值）和2型糖尿病（T2DM）发生之间的关系，目前缺乏相关研究。我们旨在评估中国成年人中CCR/WC比值与新发T2DM之间的关联。
这项前瞻性研究来自中国健康与养老追踪调查（2011年、2013年、2015年和2018年）。参与者按CCR/WC比值的三分位数分为三组。采用Cox比例风险模型来确定CCR/WC与T2DM之间的关系。
总体而言，纳入5938名参与者进行分析，其中766人在2011年至2018年间患上T2DM。与CCR/WC指数三分位数的第1组相比，第2、3组的新发T2DM风险降低（调整后风险比[HR]分别为0.772[95%置信区间0.647 - 至0.921]和0.724[0.596 - 0.880]，CCR/WC指数三分位数间的趋势p值 = 0.001）。排除前两年患有T2DM的参与者后，结果一致。
本研究表明，中国成年人中CCR/WC与T2DM风险呈负相关。对于CCR/WC水平较低的中国人，有必要进行早期检测以控制T2DM的发展。
