Riasatian Maryamsadat, Mazloomi Seyed Mohammad, Ahmadi Afsane, Derakhshan Zahra, Rajabi Saeed
Department of Community Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Nutrition Research Center, School of Nutrition and Food Sciences, Department of Clinical Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran.
Heliyon. 2023 Jun 23;9(6):e17518. doi: 10.1016/j.heliyon.2023.e17518. eCollection 2023 Jun.
This study aims to evaluate the effect of fermented synbiotic soy milk containing Lactobacillus acidophilus, Bifidobacterium lactis, and inulin on a series of hematological and oxidative stress parameters, as well as serum lead levels in rats. In this study, 56 male Sprague-Dawley rats were randomly assigned to assess probiotics (L. acidophilus or B. lactis), probiotics with prebiotics (i.e., inulin), and the corresponding controls. Several hematologic parameters (red blood cell (RBC)), hematocrit (HCT) and hemoglobin (Hgb)), serum lead levels, superoxide dismutase (SOD) activity, and malondialdehyde (MDA) presence was measured to evaluate changes on day 42. Although a significant difference was observed in serum lead levels, there were no significant changes in hematological and oxidative stress parameters between the study groups. In conclusion, this study demonstrates that administering synbiotic fermented soy milk containing the probiotic Lactobacillus acidophilus and the prebiotic inulin may significantly improve serum lead levels in rats.
本研究旨在评估含有嗜酸乳杆菌、乳酸双歧杆菌和菊粉的发酵合生元豆浆对大鼠一系列血液学和氧化应激参数以及血清铅水平的影响。在本研究中，56只雄性Sprague-Dawley大鼠被随机分组，以评估益生菌（嗜酸乳杆菌或乳酸双歧杆菌）、益生菌与益生元（即菊粉）以及相应的对照组。在第42天测量了几个血液学参数（红细胞（RBC）、血细胞比容（HCT）和血红蛋白（Hgb））、血清铅水平、超氧化物歧化酶（SOD）活性和丙二醛（MDA）含量，以评估变化情况。尽管在血清铅水平上观察到显著差异，但研究组之间的血液学和氧化应激参数没有显著变化。总之，本研究表明，给予含有益生菌嗜酸乳杆菌和益生元菊粉的合生元发酵豆浆可能会显著改善大鼠的血清铅水平。
