Department of General Surgery, Second Hospital of Lanzhou University, Lanzhou, Gansu, 730000, China.
College of Chemistry & Chemical Engineering, Lanzhou University, Lanzhou, 730000, China.
Nanomedicine (Lond). 2023 May;18(12):891-905. doi: 10.2217/nnm-2023-0096. Epub 2023 Jul 6.
Exploring a nanoscale targeted drug-delivery system (DDS) for oxaliplatin (Oxa) to improve its therapeutic effect in colorectal cancer. Nanoparticles were prepared using zeolitic imidazole framework-8 (ZIF-8) modified by hyaluronic acid oligosaccharide (oHA) as an Oxa carrier (oHA@ZIF-8@Oxa). After multiple characterizations, the therapeutic efficacy of the DDS was evaluated by cytotoxicity testing and a nude mouse tumor transplantation experiment . The results of characterization showed the DDS was homogeneous in morphology and uniform in dispersion. The drug loading of Oxa was 11.82% and the encapsulation efficiency was 90.8%. The cytotoxicity test and experiments showed that oHA@ZIF-8@Oxa had a more significant anticolorectal cancer effect than free Oxa. This work offers a promising potential DDS for enhancing the anticolorectal cancer effect of Oxa.
探索一种用于奥沙利铂（Oxa）的纳米靶向药物传递系统（DDS），以提高其在结直肠癌中的治疗效果。使用透明质酸寡糖（oHA）修饰的沸石咪唑骨架-8（ZIF-8）作为 Oxa 载体（oHA@ZIF-8@Oxa）制备纳米颗粒。经过多次表征，通过细胞毒性试验和裸鼠肿瘤移植实验评估了 DDS 的治疗效果。表征结果表明，DDS 在形态上均匀，分散均匀。Oxa 的载药量为 11.82%，包封率为 90.8%。细胞毒性试验和实验表明，oHA@ZIF-8@Oxa 比游离 Oxa 具有更显著的抗结直肠癌作用。这项工作为增强奥沙利铂的抗结直肠癌效果提供了一种有前途的潜在 DDS。
