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OXA-CuS@UiO-66-NH 作为奥沙利铂的药物传递系统用于结直肠癌细胞。

OXA-CuS@UiO-66-NH as a drug delivery system for Oxaliplatin to colorectal cancer cells.

机构信息

Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

出版信息

J Mater Sci Mater Med. 2022 Feb 28;33(3):26. doi: 10.1007/s10856-021-06574-y.

DOI:10.1007/s10856-021-06574-y
PMID:35226206
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8885473/
Abstract

In this work, UiO-66-NH was used to prepare a new delivery system by incorporating copper sulfide (CuS) into the pores. The CuS nanoparticles (NPs) were prepared to enhance the anticancer effects of Oxaliplatin (OXA) against colorectal cancer. The oxaliplatin was loaded into CuS@UiO-66-NH. To characterize and investigate their cytotoxicity effects, powder X-ray diffraction (PXRD), Fourier transformation infrared spectroscopy (FT-IR), Brunauer-Emmett-Teller (BET) analysis, UV-Visible analysis, inductively coupled plasma mass spectrometry (ICP-MS), and MTT assay were considered to be performed. According to the observations, the cytotoxicity of OXA-CuS@UiO-66-NH was greater than that of the OXA alone.

摘要

在这项工作中，UiO-66-NH 被用于通过将硫化铜（CuS）掺入孔中来制备新的递药系统。制备了硫化铜纳米粒子（NPs）以增强奥沙利铂（OXA）对结直肠癌的抗癌作用。奥沙利铂被载入 CuS@UiO-66-NH。为了对其进行表征和研究细胞毒性作用，考虑进行了粉末 X 射线衍射（PXRD）、傅里叶变换红外光谱（FT-IR）、BET 分析、紫外-可见分析、电感耦合等离子体质谱（ICP-MS）和 MTT 测定。根据观察结果，OXA-CuS@UiO-66-NH 的细胞毒性大于单独的 OXA。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ab8/8885473/3bd1a2f6a161/10856_2021_6574_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ab8/8885473/ebd653845c16/10856_2021_6574_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ab8/8885473/5f0e4466200b/10856_2021_6574_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ab8/8885473/a56fe11b6b30/10856_2021_6574_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ab8/8885473/bb11d9657b1a/10856_2021_6574_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ab8/8885473/cbf87a0a5f26/10856_2021_6574_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ab8/8885473/98465fbef9cb/10856_2021_6574_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ab8/8885473/3bd1a2f6a161/10856_2021_6574_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ab8/8885473/ebd653845c16/10856_2021_6574_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ab8/8885473/5f0e4466200b/10856_2021_6574_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ab8/8885473/a56fe11b6b30/10856_2021_6574_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ab8/8885473/bb11d9657b1a/10856_2021_6574_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ab8/8885473/cbf87a0a5f26/10856_2021_6574_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ab8/8885473/98465fbef9cb/10856_2021_6574_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ab8/8885473/3bd1a2f6a161/10856_2021_6574_Fig7_HTML.jpg

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