Wang Nuoya, Chen Liqing, Huang Wei, Gao Zhonggao, Jin Mingji
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Nanomaterials (Basel). 2024 Mar 22;14(7):557. doi: 10.3390/nano14070557.
Colorectal cancer (CRC) is a common malignant tumor, and traditional treatments include surgical resection and radiotherapy. However, local recurrence, distal metastasis, and intestinal obstruction are significant problems. Oral nano-formulation is a promising treatment strategy for CRC. This study introduces physiological and environmental factors, the main challenges of CRC treatment, and the need for a novel oral colon-targeted drug delivery system (OCDDS). This study reviews the research progress of controlled-release, responsive, magnetic, targeted, and other oral nano-formulations in the direction of CRC treatment, in addition to the advantages of oral colon-targeted nano-formulations and concerns about the oral delivery of related therapeutic agents to inspire related research.
结直肠癌（CRC）是一种常见的恶性肿瘤，传统治疗方法包括手术切除和放疗。然而，局部复发、远处转移和肠梗阻是严重问题。口服纳米制剂是一种有前景的CRC治疗策略。本研究介绍了生理和环境因素、CRC治疗的主要挑战以及新型口服结肠靶向给药系统（OCDDS）的必要性。本研究综述了控释、响应性、磁性、靶向性等口服纳米制剂在CRC治疗方向上的研究进展，以及口服结肠靶向纳米制剂的优势和对相关治疗药物口服给药的担忧，以启发相关研究。
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