B. Atchabarov Scientific-Research Institute of Fundamental and Applied Medicine, S.D. Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan.
Department of Public Health, Public Opinion Research Centre, Almaty, Republic of Kazakhstan.
Epidemiol Infect. 2023 Jul 6;151:e116. doi: 10.1017/S0950268823001085.
This study aimed to analyse the seroprevalence of SARS-CoV-2 in Kazakhstan. This is a cross-sectional study of adult population in Kazakhstan for the period from October 2021 to May 2022. For the study, 6 720 people aged 18 to 69 were recruited (from 17 regions). The demographic data were collected and analysed. Gender was evenly distributed (males 49.9%, females 50.1%). Women exhibited a higher seroprevalence than men (IgM 20.7% vs 17.9% and IgG 46.1% vs 41.5%). The highest prevalence of IgM was found in the age group of 30-39. However, the highest prevalence of IgG was detected in the age group of 60-69. The seroprevalence of IgG increased across all groups (from 39.7% in 18-29 age groups to 53.1% in 60-69 age groups). The odds for a positive test were significantly increased in older age groups 50-59 ( < 0.0001) and 60-69 ( < 0.0001). The odds of a positive test were 1.12 times higher in females compared to males ( = 0.0294). The odds for a positive test were significantly higher in eight regions (Astana, Akmola, Atyrau, Western Kazakhstan region, Kostanai, Turkestan, Eastern Kazakhstan region, and Shymkent) compared to Almaty city. The odds of a positive test were three times higher in Astana and the Western Kazakhstan region than in Almaty city. In urban areas, the odds of a positive test were 0.75 times lower than in rural areas ( < 0.0001). The study's results showed an adequate level of seroprevalence (63%) that exceeds the essential minimum of herd immunity indicators in the country. There was significant geographic variability with a higher prevalence of IgG/IgM antibodies to SARS-CoV-2 in rural areas.
本研究旨在分析哈萨克斯坦的 SARS-CoV-2 血清流行率。这是一项针对哈萨克斯坦成年人的横断面研究，研究时间为 2021 年 10 月至 2022 年 5 月。在这项研究中，共招募了 6720 名年龄在 18 至 69 岁的人（来自 17 个地区）。收集和分析了人口统计学数据。男性和女性的性别分布均匀（男性占 49.9%，女性占 50.1%）。女性的血清阳性率高于男性（IgM 为 20.7%比 17.9%，IgG 为 46.1%比 41.5%）。IgM 阳性率最高的年龄组为 30-39 岁。然而，IgG 阳性率最高的年龄组为 60-69 岁。所有年龄组的 IgG 血清阳性率均有所增加（从 18-29 岁年龄组的 39.7%增加到 60-69 岁年龄组的 53.1%）。50-59 岁（<0.0001）和 60-69 岁（<0.0001）年龄组的阳性检测几率显著增加。与男性相比，女性的阳性检测几率高 1.12 倍（=0.0294）。与阿拉木图市相比，有 8 个地区（阿斯塔纳、阿克莫拉、阿特劳、西哈萨克斯坦地区、科斯塔奈、突厥斯坦、东哈萨克斯坦地区和希姆肯特）的阳性检测几率显著更高。阿斯塔纳和西哈萨克斯坦地区的阳性检测几率是阿拉木图市的三倍。在城市地区，阳性检测几率比农村地区低 0.75 倍（<0.0001）。研究结果显示，血清流行率（63%）处于适当水平，超过了该国基本最低群体免疫指标。存在显著的地域差异，农村地区 SARS-CoV-2 IgG/IgM 抗体的阳性率更高。
