School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, 211816, P. R. China.
Macromol Biosci. 2023 Nov;23(11):e2300141. doi: 10.1002/mabi.202300141. Epub 2023 Jul 11.
Microneedles are a promising transdermal drug delivery system that has the advantages of minimal invasiveness, painlessness, and on-demand drug delivery compared with commonly used medical techniques. Natural resources are developed as next-generation materials for microneedles with varying degrees of success. Among them, silk fibroin is a natural polymer obtained from silkworms with good biocompatibility, high hardness, and controllable biodegradability. These properties provide many opportunities for integrating silk fibroin with implantable microneedle systems. In this review, the research progress of silk fibroin microneedles in recent years is summarized, including their materials, processing technology, detection, drug release methods, and applications. Besides, the research and development of silk fibroin in a multidimensional way are analyzed. Finally, it is expected that silk fibroin microneedles will have excellent development prospects in various fields.
微针是一种有前途的经皮给药系统，与常用的医疗技术相比，具有微创、无痛和按需给药的优点。天然资源被开发为微针的下一代材料，取得了不同程度的成功。其中，丝素蛋白是一种从蚕茧中提取的天然聚合物，具有良好的生物相容性、较高的硬度和可控的生物降解性。这些特性为丝素蛋白与可植入微针系统的结合提供了许多机会。本文综述了近年来丝素蛋白微针的研究进展，包括其材料、加工技术、检测、药物释放方法及应用等方面。此外，还分析了丝素蛋白的多维研究进展。最后，预计丝素蛋白微针在各个领域将具有广阔的发展前景。
