Bidari Sara, Zendehdel Morteza, Hassanpour Shahin, Rahmani Behrooz
Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Int J Dev Neurosci. 2023 Oct;83(6):546-551. doi: 10.1002/jdn.10285. Epub 2023 Jul 6.
Evidence supports that music can modulate many physiological roles, exerting clear effects on the central nervous system. For this effect to be positive, music should be tuned at a frequency of 432 Hz. This study aims to determine the effects of prenatal exposure to music on reflexive motor behaviors in mice offspring. Six pregnant female NMRI mice (8-10 weeks old) were randomly and equally allocated into two groups. Group 1 as control was placed in a normal housing area (average room noise 35 dB), and Group 2 was exposed to music pitched at 432 Hz for 2 h a day played at constant volume (75/80 dB) during pregnancy. Following delivery, four pups from each pregnant mouse were selected, and reflexive motor behaviors including ambulation, hind-limb foot angle, surface righting, grip strength, front- and hind-limb suspension, and negative geotaxis were determined. Based on the findings, prenatal exposure to music significantly increased ambulation score, grip strength, and front- and hind-limb suspension compared to the control group (P < 0.05). Also, prenatal exposure to music significantly decreased hind-limb foot angle, negative geotaxis, and surface righting compared to the control group (P < 0.05). These results suggested that music exposure during pregnancy had a significant positive effect on all tested reflexive motor behaviors in mice offspring.
有证据支持音乐可以调节多种生理作用，对中枢神经系统产生明显影响。为了使这种影响是积极的，音乐应以432赫兹的频率调音。本研究旨在确定产前接触音乐对小鼠后代反射性运动行为的影响。将6只怀孕的雌性NMRI小鼠（8-10周龄）随机且平均分为两组。第1组作为对照组置于正常饲养区域（平均房间噪音35分贝），第2组在怀孕期间每天暴露于频率为432赫兹的音乐中2小时，音量恒定（75/80分贝）。分娩后，从每只怀孕小鼠中挑选4只幼崽，测定其反射性运动行为，包括行走、后肢足角、表面翻正、握力、前肢和后肢悬吊以及负趋地性。基于这些发现，与对照组相比，产前接触音乐显著提高了行走得分、握力以及前肢和后肢悬吊能力（P < 0.05）。此外，与对照组相比，产前接触音乐显著降低了后肢足角、负趋地性和表面翻正能力（P < 0.05）。这些结果表明，孕期接触音乐对小鼠后代所有测试的反射性运动行为都有显著的积极影响。
