Department of Clinical Pharmacology and Toxicology, St Vincent's Hospital Sydney, Sydney, New South Wales, Australia.
Medicines Intelligence Centre for Research Excellence, University of New South Wales, Sydney, New South Wales, Australia.
Intern Med J. 2023 Jul;53(7):1284-1287. doi: 10.1111/imj.16159. Epub 2023 Jul 6.
With the increasing costs of drug development, repurposing of low-cost medicines for new indications has never been more important. However, there are multiple barriers to repurposing, particularly for off-patent medicines, and limited incentives for the pharmaceutical industry to sponsor registration and public subsidy listing. Here, we explore these barriers and their consequences and provide examples of successful repurposing strategies.
随着药物开发成本的不断增加，为新适应症重新利用低成本药物从未如此重要。然而，重新利用存在多种障碍，特别是对于已过专利期的药物，而且制药行业没有充分的动机来赞助注册和公共补贴上市。在这里，我们探讨这些障碍及其后果，并提供成功的重新利用策略的例子。
