血清铁蛋白作为类风湿关节炎患者铁反应性贫血的指标。
Serum ferritin as indicator of iron responsive anaemia in patients with rheumatoid arthritis.
作者信息
Hansen T M, Hansen N E
出版信息
Ann Rheum Dis. 1986 Jul;45(7):596-602. doi: 10.1136/ard.45.7.596.
In order to test the hypothesis that serum ferritin below 60 micrograms/l is a good indicator of iron deficiency in patients with rheumatoid arthritis peroral iron was given to 67 patients with active rheumatoid arthritis over a three month period. A rise in haemoglobin concentration was taken as evidence of iron responsive anaemia. In anaemic patients serum ferritin below 60 micrograms/l was a good indicator of iron responsive anaemia, with a predictive value of 83%. Although high plasma transferrin and low mean cell volume showed similar predictive values, more patients with iron deficiency anaemia could be diagnosed by serum ferritin measurements than by other conventional blood tests. In contrast, the predictive value of serum ferritin above 60 micrograms/l was low (50%). The test was of no predictive value in non-anaemic patients. In patients with anaemia and active rheumatoid arthritis serum ferritin is the best blood test currently available for the prediction of iron responsive anaemia.
为了验证类风湿关节炎患者血清铁蛋白低于60微克/升是缺铁的良好指标这一假设，在三个月的时间里，对67例活动性类风湿关节炎患者口服铁剂。血红蛋白浓度升高被视为铁反应性贫血的证据。在贫血患者中，血清铁蛋白低于60微克/升是铁反应性贫血的良好指标，预测值为83%。尽管高血浆转铁蛋白和低平均红细胞体积显示出相似的预测值，但通过血清铁蛋白测量诊断出的缺铁性贫血患者比通过其他传统血液检查诊断出的更多。相比之下，血清铁蛋白高于60微克/升的预测值较低（50%）。该检测对非贫血患者无预测价值。在贫血且患有活动性类风湿关节炎的患者中，血清铁蛋白是目前预测铁反应性贫血的最佳血液检测方法。
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