Hellman S, Harris J R, Levene M B
Cancer. 1980 Aug 15;46(4 Suppl):988-94. doi: 10.1002/1097-0142(19800815)46:4+<988::aid-cncr2820461323>3.0.co;2-o.
The results of the treatment of 176 patients with early breast cancer, using radiation therapy without mastectomy are reported. The likelihood of local recurrence was 5% for Stage I patients and 7% for Stage II patients. Local control was significantly greater in those patients receiving and iridium implant (1/73 vs. 10/111, P less than .05). The cumulative survival probability at five years is 96% for Stage I and 68% for Stage II. Local control with good cosmetic results is greatly influenced by surgical and radiotherapeutic technique. Gross tumor resection with careful reapproximation of the breast tissue and well-placed incisions facilitates the radiation therapy. Homogeneous external beam radiation to the breast and draining lymph nodes (4500--5000 rads) and supplemental local radiation to the sites of the primary lesion (in this series using interstitial implantation) are recommended.
报告了176例早期乳腺癌患者在不进行乳房切除术的情况下采用放射治疗的治疗结果。I期患者局部复发的可能性为5%，II期患者为7%。接受铱植入的患者局部控制效果明显更好（1/73对10/111，P<0.05）。I期患者五年累积生存概率为96%，II期患者为68%。手术和放射治疗技术对获得良好美容效果的局部控制有很大影响。对乳腺组织进行仔细重新缝合和切口位置合适的大体肿瘤切除术有助于放射治疗。建议对乳房和引流淋巴结进行均匀的外照射（4500-5000拉德），并对原发病变部位进行补充局部照射（本系列采用组织间植入）。
