Murrell D S, Powell K, De Winter J
Clin Radiol. 1981 Jan;32(1):41-6. doi: 10.1016/s0009-9260(81)80246-2.
Twenty-seven patients with a T1 or T2 N0M0 breast carcinoma were treated by local excision of the lump followed by radical radiotherapy, using orthovoltage X-rays. The crude survival rate was 100% at three years, 92% at five years, 95% at 10 years. The local recurrence rate was 8% at three years, 12% at five years, 10.5% at 10 years. The radiation dose needed to be tumour lethal is discussed. Our results and those of papers quoted indicate that 4500--5000 cGy (rad) in five weeks, given in five fractions per week, is optimal, provided the primary tumour has ben removed. A further 1000--2000 cGy to the lumpectomy site reduces the incidence of local recurrence. The cosmetic results of our treatment are illustrated. Some telangiectasis was seen but the general appearance and texture of the treated breasts was satisfactory.
27例T1或T2 N0M0期乳腺癌患者接受了肿块局部切除，随后采用正电压X线进行根治性放疗。三年时的粗生存率为100%，五年时为92%，十年时为95%。三年时局部复发率为8%，五年时为12%，十年时为10.5%。讨论了肿瘤致死所需的辐射剂量。我们的结果以及所引用论文的结果表明，若原发肿瘤已切除，每周分五次给予4500 - 5000厘戈瑞（拉德），持续五周是最佳方案。对乳房肿块切除部位再追加1000 - 2000厘戈瑞可降低局部复发率。展示了我们治疗的美容效果。可见一些毛细血管扩张，但治疗后乳房的总体外观和质地令人满意。
