Wolf Jonas, de Souza Ana Paula, Schardosim Raine Fogliati de Carli, Pille Arthur, Maccari Juçara Gasparetto, Mutlaq Mohamed Parrini, Nasi Luiz Antonio
Value Management Office, Medical Manager at Hospital Moinhos de Vento, Porto Alegre, RS, Brazil.
Researcher at Hospital Moinhos de Vento, Porto Alegre, RS, Brazil.
Arch Virol. 2023 Jul 6;168(8):202. doi: 10.1007/s00705-023-05833-3.
Dengue is a viral disease transmitted by mosquitoes that has spread rapidly across all continents in recent years. There are four distinct but closely related serotypes of the virus that causes dengue (DENV-1, DENV-2, DENV-3, and DENV-4). In the present study, we evaluated temporal spreading and molecular evolution of dengue virus (DENV) serotypes. Bayesian coalescent analysis was performed to study viral evolution, and it was estimated that the most recent common ancestor of DENV-1 was present in 1884 in Southeast Asia, that of DENV-2 was present in 1723 in Europe, that of DENV-3 was present in 1921 in Southeast Asia, and that of DENV-4 was present in 1876 in Southeast Asia. DENV appears to have originated in Spain in approximately 1682, and it was disseminated in Asia and Oceania in approximately 1847. After this period, the virus was introduced into North America in approximately 1890. In South America, it was first disseminated to Ecuador in approximately 1897 and then to Brazil in approximately 1910. Dengue has had a significant impact on global health worldwide, and the present study provides an overview of the molecular evolution of DENV serotypes.
登革热是一种由蚊子传播的病毒性疾病，近年来已在各大洲迅速传播。导致登革热的病毒有四种不同但密切相关的血清型（DENV-1、DENV-2、DENV-3和DENV-4）。在本研究中，我们评估了登革热病毒（DENV）血清型的时间传播和分子进化。进行了贝叶斯合并分析以研究病毒进化，据估计，DENV-1的最近共同祖先于1884年出现在东南亚，DENV-2的最近共同祖先于1723年出现在欧洲，DENV-3的最近共同祖先于1921年出现在东南亚，DENV-4的最近共同祖先于1876年出现在东南亚。DENV似乎于1682年左右起源于西班牙，并于1847年左右传播到亚洲和大洋洲。在此之后，该病毒于1890年左右被引入北美。在南美洲，它于1897年左右首次传播到厄瓜多尔，然后于1910年左右传播到巴西。登革热对全球健康产生了重大影响，本研究概述了DENV血清型的分子进化。
