Spatial Ecology and Epidemiology Group, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK.
Spatial Ecology and Epidemiology Group, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK.
Trends Microbiol. 2014 Mar;22(3):138-46. doi: 10.1016/j.tim.2013.12.011. Epub 2014 Jan 24.
Since the first isolation of dengue virus (DENV) in 1943, four types have been identified. Global phenomena such as urbanization and international travel are key factors in facilitating the spread of dengue. Documenting the type-specific record of DENV spread has important implications for understanding patterns in dengue hyperendemicity and disease severity as well as vaccine design and deployment strategies. Existing studies have examined the spread of DENV types at regional or local scales, or described phylogeographic relationships within a single type. Here we summarize the global distribution of confirmed instances of each DENV type from 1943 to 2013 in a series of global maps. These show the worldwide expansion of the types, the expansion of disease hyperendemicity, and the establishment of an increasingly important infectious disease of global public health significance.
自 1943 年首次分离出登革病毒（DENV）以来，已经确定了四种类型。城市化和国际旅行等全球现象是促进登革热传播的关键因素。记录 DENV 传播的特定类型记录对于了解登革热高度流行和疾病严重程度的模式以及疫苗设计和部署策略具有重要意义。现有研究已经在区域或地方范围内研究了 DENV 类型的传播，或者描述了单一类型内的系统地理学关系。在这里，我们在一系列全球地图中总结了 1943 年至 2013 年期间每种 DENV 类型的确诊病例的全球分布情况。这些图显示了该类型在全球范围内的扩展，疾病高度流行的扩展以及一种日益重要的传染病的建立，对全球公共卫生具有重要意义。
