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水痘带状疱疹病毒相关性非坏死性视网膜炎：病例报告

Varicella zoster virus-associated non-necrotizing retinitis: case report.

作者信息

Rym Maamouri, Yasmine Houman, Marwa Abdelaziz, Imen Helal, Monia Cheour

机构信息

Department of Ophthalmology, Habib Thameur Hospital, 3, Rue Ali Ben Ayed, 1089, Montfleury, Tunis, Tunisia.

Department of Pathology, Habib Thameur Hospital, Boulevard du 9 Avril 1938, 1006, Tunis, Tunisia.

出版信息

J Ophthalmic Inflamm Infect. 2023 Jul 6;13(1):31. doi: 10.1186/s12348-023-00353-2.

DOI:10.1186/s12348-023-00353-2
PMID:37410194
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10326174/
Abstract

PURPOSE

To describe clinical features and the course of a case of non-necrotizing herpetic retinitis secondary to Varicella zoster virus (VZV).

MATERIEL AND METHODS

A single case report documented with multimodal imaging.

RESULTS

A 52-year-old female patient with a past medical history of diabetes mellitus who presented with painful red right eye (OD). Ophthalmic examination showed perilimbal conjunctival nodule, granulomatous anterior uveitis, sectoral iris atrophy and increased intraocular pressure. Fundus examination in OD revealed posterior multifocal retinitis. Left eye examination was unremarkable. Polymerase chain reaction (PCR) of aqueous humor sample confirmed the presence of VZV DNA. Systemic antiviral therapy allowed the improvement of intraocular inflammation and disappearance of the retinal non necrotizing retinitis after one year of regular follow-up.

CONCLUSION

Non-necrotizing retinitis is an underdiagnosed form of VZV ocular infection.

摘要

目的

描述1例水痘带状疱疹病毒（VZV）继发的非坏死性疱疹性视网膜炎的临床特征及病程。

材料与方法

一份采用多模态成像记录的单病例报告。

结果

一名52岁女性患者，既往有糖尿病病史，出现右眼（OD）疼痛、眼红。眼科检查显示角膜缘结膜结节、肉芽肿性前葡萄膜炎、扇形虹膜萎缩及眼压升高。右眼眼底检查发现后极部多灶性视网膜炎。左眼检查未见异常。房水样本的聚合酶链反应（PCR）证实存在VZV DNA。经过一年的定期随访，全身抗病毒治疗使眼内炎症得到改善，视网膜非坏死性视网膜炎消失。

结论

非坏死性视网膜炎是VZV眼部感染的一种诊断不足的形式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7369/10326174/0ff0845f799f/12348_2023_353_Fig9_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7369/10326174/7ddb8e532757/12348_2023_353_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7369/10326174/90f64a9830ac/12348_2023_353_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7369/10326174/27b5471f8608/12348_2023_353_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7369/10326174/545ea2ce61b8/12348_2023_353_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7369/10326174/0ff0845f799f/12348_2023_353_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7369/10326174/45cc35edd285/12348_2023_353_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7369/10326174/05b388eb8380/12348_2023_353_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7369/10326174/6cb9ec73bfae/12348_2023_353_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7369/10326174/64868c516c17/12348_2023_353_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7369/10326174/7ddb8e532757/12348_2023_353_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7369/10326174/90f64a9830ac/12348_2023_353_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7369/10326174/27b5471f8608/12348_2023_353_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7369/10326174/545ea2ce61b8/12348_2023_353_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7369/10326174/0ff0845f799f/12348_2023_353_Fig9_HTML.jpg

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Long-term follow-up of herpetic non-necrotizing retinopathy with occlusive retinal vasculitis and neovascularization.伴有视网膜血管闭塞和新生血管形成的疱疹性非坏死性视网膜病变的长期随访
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