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造血集落形成对不同骨髓细胞数量的需求以及W/Wv贫血曲线

Different marrow cell number requirements for the haemopoietic colony formation and the curve of the W/Wv anemia.

作者信息

Wiktor-Jedrzejczak W, Szczylik C, Gónaś P, Sharkis S J, Ahmed A

出版信息

Experientia. 1979 Apr 15;35(4):546-7. doi: 10.1007/BF01922761.

DOI:10.1007/BF01922761
PMID:374109
Abstract

The lowest cell number in the normal marrow transplant, which allows the cure of W/Wv anemia was found to be between 10(4) and 10(5). This exceeds by several times the lowest cell number necessary for the haemopoietic colony formation. Therefore, either the colony forming cell is not the haemopoietic stem cell but rather its progeny, or this cell requires an aid from some other cells to exert is activity.

摘要

正常骨髓移植中能够治愈W/Wv贫血的最低细胞数在10⁴至10⁵之间。这比造血集落形成所需的最低细胞数高出数倍。因此，要么集落形成细胞不是造血干细胞，而是其后代，要么该细胞需要其他一些细胞的辅助才能发挥其活性。

相似文献

1
Different marrow cell number requirements for the haemopoietic colony formation and the curve of the W/Wv anemia.造血集落形成对不同骨髓细胞数量的需求以及W/Wv贫血曲线
Experientia. 1979 Apr 15;35(4):546-7. doi: 10.1007/BF01922761.
2
Aging and hematopoiesis. II. The ability of bone marrow cells from young and aged mice to cure and maintain cure in W/Wv.衰老与造血作用。II. 年轻和老年小鼠骨髓细胞治愈W/Wv小鼠并维持治愈状态的能力。
Transplantation. 1984 Mar;37(3):300-6.
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Reconstitution of the W/Wv stem cell differentiation defect by infection with Rauscher leukemia virus.通过劳氏肉瘤病毒感染重建W/Wv干细胞分化缺陷。
J Natl Cancer Inst. 1985 Aug;75(2):361-8.
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Presence of pluripotent haemopoietic precursors in vitro (CFU-mix) in haemopoietic tissues from mice of W/Wv genotype.W/Wv基因型小鼠造血组织中多能造血前体细胞（CFU-mix）的体外存在情况。
Cell Tissue Kinet. 1982 Jan;15(1):25-9. doi: 10.1111/j.1365-2184.1982.tb01020.x.
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Regulators of stem cell proliferation in the haemopoietic tissues of W/Wv and S1/S1d mice.W/Wv和S1/S1d小鼠造血组织中干细胞增殖的调节因子。
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Susceptibility of multipotent haemopoietic stem cell deficient W/Wv mice to Plasmodium berghei-infection.多能造血干细胞缺陷型W/Wv小鼠对伯氏疟原虫感染的易感性。
Immunol Cell Biol. 1991 Oct;69 ( Pt 5):355-60. doi: 10.1038/icb.1991.51.
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Colony promoting activity and its target 'pre-CFUc' in genetically anemic mice of W/Wv genotype.W/Wv基因型遗传性贫血小鼠中的集落促进活性及其靶标“前CFUc”
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Bone Marrow Transplant. 1989 Nov;4(6):625-8.

本文引用的文献

1
SPLEEN-COLONY FORMATION IN ANEMIC MICE OF GENOTYPE WW.基因型为WW的贫血小鼠脾脏集落形成
Science. 1964 May 15;144(3620):844-6. doi: 10.1126/science.144.3620.844.
2
A STOCHASTIC MODEL OF STEM CELL PROLIFERATION, BASED ON THE GROWTH OF SPLEEN COLONY-FORMING CELLS.基于脾集落形成细胞生长的干细胞增殖随机模型
Proc Natl Acad Sci U S A. 1964 Jan;51(1):29-36. doi: 10.1073/pnas.51.1.29.
3
THE DISTRIBUTION OF COLONY-FORMING CELLS AMONG SPLEEN COLONIES.脾集落中集落形成细胞的分布
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4
A direct measurement of the radiation sensitivity of normal mouse bone marrow cells.正常小鼠骨髓细胞辐射敏感性的直接测量。
Radiat Res. 1961 Feb;14:213-22.
5
Hemopoietic colony studies. V. Effect of hemopoietic organ stroma on differentiation of pluripotent stem cells.造血集落研究。V. 造血器官基质对多能干细胞分化的影响。
J Exp Med. 1968 Jan 1;127(1):205-14. doi: 10.1084/jem.127.1.205.
6
Population of lymphoid tissues in cured W-anemic mice by donor cells.供体细胞对治愈的W贫血小鼠淋巴组织的填充情况
Transplantation. 1976 Jul;22(1):42-6. doi: 10.1097/00007890-197607000-00007.
7
The relationship between the spleen colony-forming cell and the haemopoietic stem cell.脾集落形成细胞与造血干细胞之间的关系。
Blood Cells. 1978;4(1-2):7-25.
8
Hematopoietic stem cell regulatory volumes as revealed in studies of the bgj/bgj:W/WV chimera.在bgj/bgj:W/WV嵌合体研究中揭示的造血干细胞调节体积。
J Exp Med. 1978 Apr 1;147(4):1189-97. doi: 10.1084/jem.147.4.1189.
9
Theta-sensitive cell and erythropoiesis: identification of a defect in W/Wv anemic mice.θ敏感细胞与红细胞生成：W/Wv贫血小鼠缺陷的鉴定。
Science. 1977 Apr 15;196(4287):313-5. doi: 10.1126/science.322288.
10
The identification in adult bone marrow of pluripotent and restricted stem cells of the myeloid and lymphoid systems.在成人骨髓中鉴定出多能以及髓系和淋巴系的定向干细胞。
J Exp Med. 1977 Jun 1;145(6):1567-79. doi: 10.1084/jem.145.6.1567.