Lubrano R, Taccone-Gallucci M, Mazzarella V, Bandino D, Citti G, Elli M, Giardini O, Casciani C U
Artif Organs. 1986 Jun;10(3):245-8. doi: 10.1111/j.1525-1594.1986.tb02553.x.
It has been reported that increased peroxidation of the polyunsaturated fatty acids in the erythrocyte membranes is one of the causes of chronic hemolysis in uremic patients on hemodialysis and that therapeutic doses of vitamin E are effective in reducing peroxidation, improving the hematocrit. The present study shows how the reduced peroxidation, induced by a course with therapeutic doses of vitamin E, is paralleled by a significant reduction of plasma hemoglobin concentrations at the end of the dialysis and by a significant improvement of erythrocyte osmotic resistance. The findings lead to the suggestion that the administration of tocopherol to patients on chronic hemodialysis for end-stage renal disease may be beneficial in improving anemia, acting via a reduction of lipid peroxidation of the red blood cell membranes. Whether this can reduce the need for the transfusions can be assessed only with a longitudinal long-term study, which is also necessary to determine whether the preliminary findings of this report have important clinical applications.
据报道，红细胞膜中多不饱和脂肪酸过氧化增加是接受血液透析的尿毒症患者慢性溶血的原因之一，且治疗剂量的维生素E可有效减少过氧化反应，提高血细胞比容。本研究表明，在透析结束时，通过给予治疗剂量的维生素E所诱导的过氧化反应降低，与血浆血红蛋白浓度的显著降低以及红细胞渗透抵抗力的显著改善同时出现。这些发现表明，对于终末期肾病接受慢性血液透析的患者，给予生育酚可能有助于改善贫血，其作用机制是减少红细胞膜的脂质过氧化。只有通过长期纵向研究才能评估这是否可以减少输血需求，而这对于确定本报告的初步发现是否具有重要临床应用价值也是必要的。
