Del Bino G, Silvestrini R, Costa A, Veneroni S, Giardini R
Basic Appl Histochem. 1986;30(2):197-202.
The relation between the proliferative activity and morphologic features according to Rappaport and Kiel classifications and the Working Formulation (WF) was analyzed in a series of 123 adult patients with non-Hodgkin lymphomas. Cell kinetics was determined as in vitro 3H-thymidine labelling index (LI). A significant association was observed between low LI and follicular histology or low grade of the WF, as well as between high LI and high-grade of malignancy of the Kiel and WF. The analysis of the clinical relevance of cell kinetics on objective response to treatment showed a higher frequency (91%) of complete remission in the tumors with low proliferative activity versus tumors with high proliferative activity (48%) (p = 0.00003). Moreover, cell kinetics proved to be and important indicator of 6-year survival on the whole population of patients (66% for slowly vs 18% for fast-proliferating tumors; p less than 10(-9)) and a further discriminant within diffuse histology (68% vs 9%; p less than 0.0001), low-grade malignancy according to the Kiel (64% vs 15%; p less than 10(-8)) and low (64% vs 28%; p less than 0.005) and intermediate grades of the WF (68% vs 9%; p less than 0.0001).
对123例成年非霍奇金淋巴瘤患者，分析了根据Rappaport分类法、Kiel分类法及工作分类法（WF）确定的增殖活性与形态学特征之间的关系。细胞动力学测定采用体外3H-胸腺嘧啶核苷标记指数（LI）。观察到低LI与滤泡性组织学或WF低分级之间存在显著关联，以及高LI与Kiel和WF的高恶性分级之间存在显著关联。对细胞动力学与治疗客观反应的临床相关性分析显示，增殖活性低的肿瘤完全缓解频率较高（91%），而增殖活性高的肿瘤完全缓解频率较低（48%）（p = 0.00003）。此外，细胞动力学被证明是整个人群6年生存率的重要指标（增殖缓慢的肿瘤为66%，增殖快速的肿瘤为18%；p小于10(-9)），并且在弥漫性组织学（68%对9%；p小于0.0001）、根据Kiel分类的低恶性分级（64%对15%；p小于10(-8)）以及WF的低（64%对28%；p小于0.005）和中级分级（68%对9%；p小于0.0001）中具有进一步的鉴别作用。
