Costa A, Bonadonna G, Villa E, Valagussa P, Silvestrini R
J Natl Cancer Inst. 1981 Jan;66(1):1-5.
The labeling index (LI) was determined at the time of initial diagnosis of 88 untreated adults with non-Hodgkin's lymphomas. The frequency distribution of low (less than or equal to 4%) and high (> 4%) LI between tumors with nodular and diffuse histologic patterns was significantly different (P < 0.001): The median LI was about four times greater for diffuse lymphomas than for nodular lymphomas. LI was not correlated with either disease extent or systemic symptoms. In patients with tumors of low LI, complete remission occurred in 86% of those with modular lymphomas and in 74% of those with diffuse lymphomas. These values were significantly different from the 17 and 39% observed respectively for nodular and diffuse lymphomas with high LI. Patients with low LI had greater actuarial 4-year survival than did those with high LI (P < 10(-7)). Highly significant differences between the two kinetic groups were also observed within nodular and diffuse patterns. However, whereas the difference for nodular lymphomas was independent of histologic subtype and stage, this was not always true for all subtypes of diffuse lymphomas. LI could be a useful marker to identify prior to treatment the patients who could enter complete remission and have favorable survival. Its clinical relevance as a prognostic factor appeared superior to the Rappaport histologic classification and pathologic stage, especially in patients with nodular histology.
对88例未经治疗的非霍奇金淋巴瘤成年患者进行初始诊断时测定标记指数（LI）。结节性和弥漫性组织学模式肿瘤之间低（小于或等于4%）和高（>4%）LI的频率分布有显著差异（P<0.001）：弥漫性淋巴瘤的LI中位数约为结节性淋巴瘤的四倍。LI与疾病范围或全身症状均无相关性。在LI低的肿瘤患者中，结节性淋巴瘤患者的完全缓解率为86%，弥漫性淋巴瘤患者为74%。这些值与高LI的结节性和弥漫性淋巴瘤分别观察到的17%和39%有显著差异。LI低的患者4年精算生存率高于LI高的患者（P<10⁻⁷）。在结节性和弥漫性模式中也观察到两个动力学组之间有高度显著差异。然而，虽然结节性淋巴瘤的差异与组织学亚型和分期无关，但并非所有弥漫性淋巴瘤亚型都是如此。LI可能是一个有用的标志物，可在治疗前识别能够进入完全缓解并具有良好生存率的患者。其作为预后因素的临床相关性似乎优于Rappaport组织学分类和病理分期，尤其是在结节性组织学患者中。
