Hunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China.
Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, Hunan, China.
Aging (Albany NY). 2023 Jul 6;15(14):7324-7332. doi: 10.18632/aging.204852.
The family of Eph receptor tyrosine kinases and their Ephrin ligands system constitutes a bidirectional signaling pathway. Eph/Ephrin system coordinate a wide spectrum of pathologic processes during development, metastasis, prognosis, drug resistance and angiogenesis in carcinogenesis. Chemotherapy, surgery and radiotherapy are the most commonly used clinical treatments for primary bone tumors. Therefore, surgical resection is often unable to completely eliminate the tumor, and this is the main cause of metastasis and postoperative recurrence. A growing body of literature has been published lately revitalizing our scientific interest towards the role of Eph/Ephrins in pathogenesis and the treatment of bone tumor and bone cancer pain. This study mainly reviewed the roles of Eph/Ephrin system that has both tumor-suppressing and -promoting roles in primary bone tumors and bone cancer pain. Understanding the intracellular mechanisms of Eph/Ephrin system in tumorigenesis and metastasis of bone tumors might provide a foundation for the development of Eph/Ephrin targeted anti-cancer therapy.
Eph 受体酪氨酸激酶家族及其 Ephrin 配体系统构成了一个双向信号通路。Eph/Ephrin 系统在肿瘤发生过程中的发展、转移、预后、耐药性和血管生成中协调广泛的病理过程。化疗、手术和放疗是原发性骨肿瘤最常用的临床治疗方法。因此，手术切除往往无法完全消除肿瘤，这也是转移和术后复发的主要原因。最近发表了越来越多的文献，重新激发了我们对 Eph/Ephrins 在骨肿瘤发病机制和骨肿瘤癌痛治疗中的作用的科学兴趣。本研究主要综述了 Eph/Ephrin 系统在原发性骨肿瘤和骨癌痛中既具有肿瘤抑制作用又具有促进作用的作用。了解 Eph/Ephrin 系统在骨肿瘤发生和转移中的细胞内机制可能为开发 Eph/Ephrin 靶向抗癌治疗提供基础。
