在无过氧化物酶体患者（齐韦格综合征）大脑中检测到一系列C26 - C38多烯脂肪酸。
Detection of a homologous series of C26-C38 polyenoic fatty acids in the brain of patients without peroxisomes (Zellweger's syndrome).
作者信息
Poulos A, Sharp P, Singh H, Johnson D, Fellenberg A, Pollard A
出版信息
Biochem J. 1986 Apr 15;235(2):607-10. doi: 10.1042/bj2350607.
Abstract
The brains of patients with inherited abnormalities in peroxisomal structure and function contain greatly increased proportions of a homologous series of unique polyenoic fatty acids with carbon chain lengths ranging from 26 to 38. Based on evidence by chemical ionization and electron impact mass spectrometry before and after catalytic hydrogenation, and argentation t.l.c., these lipids have been tentatively identified as 26:5, 28:5, 30:5, 30:6, 30:7, 32:5, 32:6, 32:7, 34:5 and 34:6 fatty acids. A further two fatty acids eluting at very high temperatures from gas chromatography columns have been tentatively identified on the basis of their chemical ionization mass spectra as 36:6 and 38:6 fatty acids.
摘要
患有过氧化物酶体结构和功能遗传性异常的患者大脑中，一系列碳链长度在26至38之间的独特多烯脂肪酸同系物的比例大幅增加。基于催化氢化前后的化学电离和电子轰击质谱以及银化薄层层析的证据，这些脂质已被初步鉴定为26:5、28:5、30:5、30:6、30:7、32:5、32:6、32:7、34:5和34:6脂肪酸。另外两种从气相色谱柱在非常高的温度下洗脱的脂肪酸，根据其化学电离质谱已被初步鉴定为36:6和38:6脂肪酸。
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