Falk E S
Dermatologica. 1979;158(5):348-54.
A 74-year-old male patient with rheumatoid arthritis and Sjögren's syndrome developed pemphigus foliaceus. Clinically healthy skin tissue revealed a fluorescent band of IgM along the basal membrane and an intercellular deposit of C3 and IgG in the deepest areas of the epidermis. Similar investigations of diseased skin revealed no deposits of IgM, and C3 and IgG were spread over a large area of the epidermis, though following the same pattern. In sero-positive rheumatoid patients with and without vasculitis, C3 and IgM are frequently found in small dermal vessels immediately below the epidermis in apparently normal skin. The fluorescent band of IgM along the basal membrane is thought to be an expression of the patient's rheumatoid arthritis, in spite of the fact that this IgM site is not typically associated with rheumatoid arthritis. The change in the pattern of deposition is thought to be due to pemphigus foliaceus.
一名患有类风湿性关节炎和干燥综合征的74岁男性患者患上了落叶型天疱疮。临床健康的皮肤组织显示，沿基底膜有一条IgM荧光带，在表皮最深层有C3和IgG的细胞间沉积。对患病皮肤进行的类似检查未发现IgM沉积，C3和IgG虽呈相同模式，但分布于表皮的大片区域。在有或没有血管炎的血清阳性类风湿患者中，在看似正常皮肤的表皮正下方的小真皮血管中经常发现C3和IgM。尽管这个IgM位点通常与类风湿性关节炎无关，但沿基底膜的IgM荧光带被认为是患者类风湿性关节炎的一种表现。沉积模式的变化被认为是由于落叶型天疱疮所致。
