Teppo A M, Maury C P
Clin Exp Immunol. 1984 Jul;57(1):73-8.
An enzyme immunoassay was used to measure circulating antibodies to gluten, gliadin and to 'reticulin glycoprotein' in 25 patients with Sjögren's syndrome (SS), in 20 patients with rheumatoid arthritis without SS and in 19 patients with systemic lupus erythematosus without SS. Antibody levels to these three antigens were significantly higher in SS than in the other groups. In SS the level of antibodies to 'reticulin glycoprotein' correlated positively with the levels of antibodies to both gliadin and to gluten but not with the level of antibodies to SS-B antigen. Patients with primary SS had higher antibody levels to 'reticulin glycoprotein' than had patients with secondary SS, whereas no significant difference between primary and secondary SS was found in the levels of the antibodies to gliadin or to gluten. Circulating antibodies to gliadin, gluten and 'reticulin glycoprotein' have not been previously recognized in SS. Their occurrence suggests that small bowel injury may be a common finding in SS.
采用酶免疫分析法检测了25例干燥综合征（SS）患者、20例无SS的类风湿关节炎患者和19例无SS的系统性红斑狼疮患者血清中针对麸质、麦醇溶蛋白和“网状纤维糖蛋白”的抗体。SS患者针对这三种抗原的抗体水平显著高于其他组。在SS中，“网状纤维糖蛋白”抗体水平与麦醇溶蛋白和麸质抗体水平呈正相关，但与SS - B抗原抗体水平无关。原发性SS患者“网状纤维糖蛋白”抗体水平高于继发性SS患者，而原发性和继发性SS患者麦醇溶蛋白或麸质抗体水平无显著差异。此前在SS中尚未发现针对麦醇溶蛋白、麸质和“网状纤维糖蛋白”的循环抗体。它们的出现提示小肠损伤可能是SS中的常见表现。
