Shenzhen Key Laboratory of Marine Bioresources and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, China, 518060; Shenzhen Bay Laboratory, Shenzhen, China, 518000.
Shenzhen Key Laboratory of Marine Bioresources and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, China, 518060.
J Dairy Sci. 2023 Aug;106(8):5253-5265. doi: 10.3168/jds.2023-23254. Epub 2023 Jul 4.
Whey protein powder (PP), which is mainly derived from bovine milk, is rich in milk fat globule membrane (MFGM). The MGFM has been shown to play a role in promoting neuronal development and cognition in the infant brain. However, its role in Alzheimer's disease (AD) has not been elucidated. Here, we showed that the cognitive ability of 3×Tg-AD mice (a triple-transgenic mouse model of AD) could be improved by feeding PP to mice for 3 mo. In addition, PP ameliorated amyloid peptide deposition and tau hyperphosphorylation in the brains of AD mice. We found that PP could alleviate AD pathology by inhibiting neuroinflammation through the peroxisome proliferator-activated receptor γ (PPARγ)-nuclear factor-κB signaling pathway in the brains of AD mice. Our study revealed an unexpected role of PP in regulating the neuroinflammatory pathology of AD in a mouse model.
乳清蛋白粉（PP）主要来源于牛奶，富含乳脂肪球膜（MFGM）。研究表明，MFGM 在促进婴儿大脑中神经元发育和认知方面发挥着重要作用。然而，其在阿尔茨海默病（AD）中的作用尚未阐明。在这里，我们发现用 PP 喂养 3×Tg-AD 小鼠（AD 的三转基因小鼠模型） 3 个月可以改善其认知能力。此外，PP 还可以改善 AD 小鼠大脑中的淀粉样肽沉积和 tau 过度磷酸化。我们发现，PP 通过激活过氧化物酶体增殖物激活受体γ（PPARγ）-核因子-κB 信号通路抑制神经炎症，从而减轻 AD 小鼠大脑中的 AD 病理。我们的研究揭示了 PP 在调节 AD 神经炎症病理方面的一个意想不到的作用。
