Choi S J, Schumacher H R, Clayburne G, Rothfuss M S, Sieck M
Arthritis Rheum. 1986 Jul;29(7):889-96. doi: 10.1002/art.1780290711.
A solution containing synthetic liposomes was injected into rabbit knee joints. This induced light and electron microscopic findings very similar to those seen in acute or chronic arthritis, not attributable to any mechanism other than to spherulites, in humans. Synovial fluid studies revealed leukocytosis and abundant extracellular, and/or intracellular positively birefringent spherulites, which appeared as Maltese crosses. Histologic studies of synovial membranes showed infiltration with polymorphonuclear neutrophils or mononuclear cells. Examination of the synovial fluids and synovial membranes by electron microscopy revealed intracellular multilayered membranous arrays of varying shapes. These observations suggest that further consideration should be given to a phlogistic role for similar spherulites found in some patients.
将含有合成脂质体的溶液注入兔膝关节。这导致了光学和电子显微镜下的发现，与人类急性或慢性关节炎中所见的非常相似，除了球晶外，没有其他任何机制可解释这种现象。滑液研究显示白细胞增多，以及大量细胞外和/或细胞内正双折射球晶，呈现为马耳他十字形。滑膜的组织学研究显示有多形核中性粒细胞或单核细胞浸润。通过电子显微镜检查滑液和滑膜发现细胞内有各种形状的多层膜状排列。这些观察结果表明，对于在一些患者中发现的类似球晶的促炎作用应进一步加以考虑。
