Pei Zuowei, Zhou Rui, Yao Wei, Dong Shuang, Liu Yingshu, Gao Zhengnan
Department of Cardiology, Central Hospital of Dalian University of Technology, Dalian, China.
Department of Central Laboratory, Central Hospital of Dalian University of Technology, Dalian, China.
iScience. 2023 Jun 15;26(7):107080. doi: 10.1016/j.isci.2023.107080. eCollection 2023 Jul 21.
Type 2 diabetes mellitus (T2DM) usually develop myocardial injury and that exercise may have a positive effect on cardiac function. However, the effect of exercise intensity on cardiac function has not yet been fully examined. This study aimed to explore different exercise intensities on T2DM-induced myocardial injury. 18-week-old male mice were randomly divided into four groups: a control group, the T2DM, T2DM + medium-intensity continuous training (T2DM + MICT), and T2DM + high-intensity interval training (T2DM + HIIT) groups. In the experimental group, mice were given high-fat foods and streptozotocin for six weeks and then divided into two exercise training groups, in which mice were subjected to exercise five days per week for 24 consecutive weeks. Finally, metabolic characteristics, cardiac function, myocardial remodeling, myocardial fibrosis, oxidative stress, and apoptosis were analyzed. HIIT treatment improved cardiac function and improved myocardial injury. In conclusion, HIIT may be an effective means to guard against T2DM-induced myocardial injury.
2型糖尿病（T2DM）通常会引发心肌损伤，而运动可能对心脏功能有积极影响。然而，运动强度对心脏功能的影响尚未得到充分研究。本研究旨在探讨不同运动强度对T2DM诱导的心肌损伤的影响。将18周龄雄性小鼠随机分为四组：对照组、T2DM组、T2DM + 中等强度持续训练（T2DM + MICT）组和T2DM + 高强度间歇训练（T2DM + HIIT）组。在实验组中，给小鼠喂食高脂食物并注射链脲佐菌素六周，然后分为两个运动训练组，其中小鼠每周进行五天运动，连续进行24周。最后，分析代谢特征、心脏功能、心肌重塑、心肌纤维化、氧化应激和细胞凋亡。HIIT治疗改善了心脏功能并减轻了心肌损伤。总之，HIIT可能是预防T2DM诱导的心肌损伤的有效手段。
