You Guopeng, Xie Jinwen, Tong Wei, Zhao Shaocong
Department of Physical Education, Xiamen University of Technology, Xiamen, China.
Department of Physical Education, Changzhi Medical College, Changzhi, China.
Front Physiol. 2025 Aug 21;16:1651589. doi: 10.3389/fphys.2025.1651589. eCollection 2025.
Cardiovascular diseases (CVDs) are the world's leading cause of death, but there's a gap between scientific research and real-world treatment. Exercise is a safe and effective way to prevent and manage CVDs, yet putting it into practice faces many challenges. This review shows how exercise protects the heart by improving metabolism, reducing inflammation and cell damage, and strengthening connections between heart cells and blood vessels. Exercise establishes a multi-organ defense network involving remote organs including the brain, skeletal muscle, adipose tissue, liver, and kidneys. To bridge the gap between research and clinical use, future efforts should focus on developing exercise-like drugs, personalized workout plans, and remote rehabilitation programs.
心血管疾病（CVDs）是全球首要死因，但科学研究与实际治疗之间存在差距。运动是预防和管理心血管疾病的安全有效方式，然而将其付诸实践面临诸多挑战。本综述展示了运动如何通过改善新陈代谢、减轻炎症和细胞损伤以及加强心脏细胞与血管之间的联系来保护心脏。运动建立了一个涉及包括大脑、骨骼肌、脂肪组织、肝脏和肾脏等远端器官的多器官防御网络。为弥合研究与临床应用之间的差距，未来的努力应集中在开发类似运动的药物、个性化锻炼计划和远程康复项目上。
