• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

SDPR 通过调节脂肪酸氧化抑制胃癌 TGF-β 诱导的肿瘤转移。

SDPR Inhibits TGF-β Induced Cancer Metastasis Through Fatty Acid Oxidation Regulation in Gastric Cancer.

机构信息

Department of Oncology, The Affiliated Hospital of Southwest Medical University, Sichuan, Luzhou, 644000, China.

Department of Cardiovascular Medicine, The Affiliated Hospital of Southwest Medical University, Sichuan, Luzhou, China.

出版信息

Int J Biol Sci. 2023 Jun 4;19(10):2999-3014. doi: 10.7150/ijbs.83012. eCollection 2023.

DOI:10.7150/ijbs.83012
PMID:37416765
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10321275/
Abstract

Our previous studies have confirmed that transforming growth factor-β (TGF-β) plays an important role in tumor metastasis, and the serum deprivation protein response (SDPR) is a potential downstream target of TGF-β. However, the role and mechanism of SDPR in gastric cancer are still unclear. We performed gene microarray, bioinformation analysis, combined with and experimental verification, we identified that SDPR is significantly downregulated in gastric cancer, and participates in TGF-β-mediated tumour metastasis. Mechanically, SDPR interacts with extracellular signal-regulated kinase (ERK) and inhibits fatty acid metabolism key gene Carnitine palmitoyl transferase 1A (CPT1A) at transcriptional level by supressing ERK/PPAR pathway. Our findings suggest that the TGF-β/SDPR/CPT1A axis play an important role in the fatty acid oxidation of gastric cancer, and provides a new insight into the crosstalk of tumour microenvironments and metabolism reprogramming and suggest that strategies to intervene the fatty acid metabolism may therapy gastric cancer metastasis.

摘要

我们之前的研究证实转化生长因子-β（TGF-β）在肿瘤转移中发挥重要作用，而血清剥夺蛋白反应（SDPR）是 TGF-β的潜在下游靶标。然而，SDPR 在胃癌中的作用和机制尚不清楚。我们进行了基因微阵列、生物信息学分析，并结合体内外实验验证，确定 SDPR 在胃癌中显著下调，并参与 TGF-β 介导的肿瘤转移。机制上，SDPR 通过抑制 ERK/PPAR 通路与细胞外信号调节激酶（ERK）相互作用，并在转录水平抑制脂肪酸代谢关键基因肉碱棕榈酰转移酶 1A（CPT1A）。我们的研究结果表明，TGF-β/SDPR/CPT1A 轴在胃癌的脂肪酸氧化中发挥重要作用，为肿瘤微环境与代谢重编程的串扰提供了新的见解，并提示干预脂肪酸代谢的策略可能有助于治疗胃癌转移。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1675/10321275/f1480e47a43b/ijbsv19p2999g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1675/10321275/18393bdd8ae6/ijbsv19p2999g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1675/10321275/a5d92b3b0006/ijbsv19p2999g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1675/10321275/5c6251b0bace/ijbsv19p2999g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1675/10321275/d8cf03914e13/ijbsv19p2999g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1675/10321275/0d3ec75687ef/ijbsv19p2999g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1675/10321275/a3a6b9a368a0/ijbsv19p2999g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1675/10321275/f1480e47a43b/ijbsv19p2999g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1675/10321275/18393bdd8ae6/ijbsv19p2999g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1675/10321275/a5d92b3b0006/ijbsv19p2999g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1675/10321275/5c6251b0bace/ijbsv19p2999g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1675/10321275/d8cf03914e13/ijbsv19p2999g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1675/10321275/0d3ec75687ef/ijbsv19p2999g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1675/10321275/a3a6b9a368a0/ijbsv19p2999g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1675/10321275/f1480e47a43b/ijbsv19p2999g007.jpg

相似文献

1
SDPR Inhibits TGF-β Induced Cancer Metastasis Through Fatty Acid Oxidation Regulation in Gastric Cancer.SDPR 通过调节脂肪酸氧化抑制胃癌 TGF-β 诱导的肿瘤转移。
Int J Biol Sci. 2023 Jun 4;19(10):2999-3014. doi: 10.7150/ijbs.83012. eCollection 2023.
2
Gastric cancer adapts high lipid microenvironment via suppressing PPARG-FABP1 axis after arriving in the lymph node.胃癌转移至淋巴结后通过抑制PPARG-FABP1轴来适应高脂微环境。
Redox Biol. 2025 Jul 17;85:103759. doi: 10.1016/j.redox.2025.103759.
3
Chondroitin sulfate proteoglycan 4 increases invasion of recessive dystrophic epidermolysis bullosa-associated cutaneous squamous cell carcinoma by modifying transforming growth factor-β signalling.硫酸软骨素蛋白聚糖4通过调节转化生长因子-β信号通路增加隐性营养不良型大疱性表皮松解症相关皮肤鳞状细胞癌的侵袭性。
Br J Dermatol. 2024 Dec 23;192(1):104-117. doi: 10.1093/bjd/ljae295.
4
miR-577 Regulates TGF-β Induced Cancer Progression through a SDPR-Modulated Positive-Feedback Loop with ERK-NF-κB in Gastric Cancer.miR-577 通过与胃癌中 ERK-NF-κB 的正反馈环调节 SDPR 调控 TGF-β 诱导的癌症进展。
Mol Ther. 2019 Jun 5;27(6):1166-1182. doi: 10.1016/j.ymthe.2019.02.002. Epub 2019 Feb 10.
5
Adipocyte-derived factors induce adherent to suspension transition in breast and pancreatic cancer cells through lipid metabolic alteration.脂肪细胞衍生因子通过脂质代谢改变诱导乳腺癌和胰腺癌细胞从贴壁状态转变为悬浮状态。
Sci Rep. 2025 Aug 20;15(1):30552. doi: 10.1038/s41598-025-13309-4.
6
SLC31A1 promotes chemoresistance through inducing CPT1A-mediated fatty acid oxidation in ER-positive breast cancer.溶质载体家族31成员1（SLC31A1）通过诱导内质网阳性乳腺癌中肉碱/有机阳离子转运体1A（CPT1A）介导的脂肪酸氧化促进化疗耐药。
Neoplasia. 2025 Mar;61:101125. doi: 10.1016/j.neo.2025.101125. Epub 2025 Feb 3.
7
IMUP promotes fatty acid metabolism and lung cancer progression by regulating TGF-β/SMAD3 signaling pathway.IMUP通过调节TGF-β/SMAD3信号通路促进脂肪酸代谢和肺癌进展。
Tissue Cell. 2025 Jul 29;97:103061. doi: 10.1016/j.tice.2025.103061.
8
TGF-β and TNF-α interaction promotes the expression of MMP-9 through H3K36 dimethylation: implications in breast cancer metastasis.TGF-β 和 TNF-α 的相互作用通过 H3K36 二甲基化促进 MMP-9 的表达：在乳腺癌转移中的意义。
Front Immunol. 2024 Sep 16;15:1430187. doi: 10.3389/fimmu.2024.1430187. eCollection 2024.
9
SENP2 suppresses epithelial-mesenchymal transition of bladder cancer cells through deSUMOylation of TGF-βRI.SENP2通过去SUMO化修饰转化生长因子-β受体I（TGF-βRI）抑制膀胱癌细胞的上皮-间质转化。
Mol Carcinog. 2017 Oct;56(10):2332-2341. doi: 10.1002/mc.22687. Epub 2017 Jun 30.
10
A lipid metabolism-related gene signature for risk stratification and prognosis prediction in patients with breast cancer.一种用于乳腺癌患者风险分层和预后预测的脂质代谢相关基因特征。
Sci Rep. 2025 Jul 26;15(1):27281. doi: 10.1038/s41598-025-10879-1.

引用本文的文献

1
Multi-Omic Characterization of Epithelial-Mesenchymal Transition: Lipidomic and Metabolomic Profiles as Key Markers of TGF-β-Induced Transition in Huh7 Hepatocellular Carcinoma.上皮-间质转化的多组学特征：脂质组学和代谢组学图谱作为转化生长因子-β诱导的Huh7肝癌细胞系转化的关键标志物
Cells. 2025 Aug 10;14(16):1233. doi: 10.3390/cells14161233.
2
CPT1A Alleviates Senescence and Restores Osteogenic Differentiation of BM-MSC Through SOD2 Succinylation.肉碱/有机阳离子转运体1A通过超氧化物歧化酶2琥珀酰化减轻骨髓间充质干细胞衰老并恢复其成骨分化
J Cell Mol Med. 2025 Mar;29(5):e70473. doi: 10.1111/jcmm.70473.
3
N6-methyladenosine RNA methylation, a new hallmark of metabolic reprogramming in the immune microenvironment.

本文引用的文献

1
Soluble TGFBI aggravates the malignancy of cholangiocarcinoma through activation of the ITGB1 dependent PPARγ signalling pathway.可溶性转化生长因子β诱导蛋白通过激活整合素β1依赖性过氧化物酶体增殖物激活受体γ信号通路加重胆管癌的恶性程度。
Cell Oncol (Dordr). 2022 Apr;45(2):275-291. doi: 10.1007/s13402-022-00668-7. Epub 2022 Mar 31.
2
Up-regulation of LncRNA UCA1 by TGF-β promotes doxorubicin resistance in breast cancer cells.TGF-β 上调 LncRNA UCA1 促进乳腺癌细胞多柔比星耐药。
Immunopharmacol Immunotoxicol. 2022 Aug;44(4):492-499. doi: 10.1080/08923973.2022.2054428. Epub 2022 Mar 25.
3
Fatty acid oxidation fuels glioblastoma radioresistance with CD47-mediated immune evasion.
N6-甲基腺苷RNA甲基化，免疫微环境中代谢重编程的一个新标志。
Front Immunol. 2024 Dec 20;15:1464042. doi: 10.3389/fimmu.2024.1464042. eCollection 2024.
4
Comprehensive analysis of the prognostic and immunological role of cavins in non-small cell lung cancer.对小窝蛋白在非小细胞肺癌中的预后和免疫作用的综合分析
BMC Cancer. 2024 Dec 18;24(1):1525. doi: 10.1186/s12885-024-13280-9.
5
The ZNF263/CPT1B axis regulates fatty acid β-oxidation to affect cisplatin resistance in lung adenocarcinoma.ZNF263/CPT1B 轴调节脂肪酸 β-氧化以影响肺腺癌对顺铂的耐药性。
Pharmacogenomics J. 2024 Nov 5;24(6):33. doi: 10.1038/s41397-024-00355-w.
6
Eye on the horizon: The metabolic landscape of the RPE in aging and disease.关注前沿：衰老和疾病中视网膜色素上皮的代谢图景。
Prog Retin Eye Res. 2025 Jan;104:101306. doi: 10.1016/j.preteyeres.2024.101306. Epub 2024 Oct 19.
7
High expression of ABL2 promotes gastric cancer cells migration, invasion and proliferation via the TGF-β and YAP signaling pathways.ABL2的高表达通过TGF-β和YAP信号通路促进胃癌细胞的迁移、侵袭和增殖。
J Cancer. 2024 Sep 9;15(17):5719-5728. doi: 10.7150/jca.99307. eCollection 2024.
8
Proteomic study on nintedanib in gastric cancer cells.蛋白质组学研究尼达尼布在胃癌细胞中的作用。
PeerJ. 2024 Feb 21;12:e16771. doi: 10.7717/peerj.16771. eCollection 2024.
脂肪酸氧化通过 CD47 介导的免疫逃避为胶质母细胞瘤的放疗抵抗供能。
Nat Commun. 2022 Mar 21;13(1):1511. doi: 10.1038/s41467-022-29137-3.
4
Global Incidence and Mortality of Gastric Cancer, 1980-2018.全球 1980-2018 年胃癌发病率和死亡率。
JAMA Netw Open. 2021 Jul 1;4(7):e2118457. doi: 10.1001/jamanetworkopen.2021.18457.
5
Hypoxia via ERK Signaling Inhibits Hepatic PPARα to Promote Fatty Liver.缺氧通过 ERK 信号抑制肝 PPARα 以促进脂肪肝。
Cell Mol Gastroenterol Hepatol. 2021;12(2):585-597. doi: 10.1016/j.jcmgh.2021.03.011. Epub 2021 Mar 30.
6
Lipid metabolism and cancer.脂代谢与癌症。
J Exp Med. 2021 Jan 4;218(1). doi: 10.1084/jem.20201606.
7
Long-chain fatty acyl-CoA synthetase 1 promotes prostate cancer progression by elevation of lipogenesis and fatty acid beta-oxidation.长链脂肪酸辅酶 A 合成酶 1 通过增加脂肪生成和脂肪酸β氧化促进前列腺癌的进展。
Oncogene. 2021 Mar;40(10):1806-1820. doi: 10.1038/s41388-021-01667-y. Epub 2021 Feb 9.
8
Inhibitors of Fatty Acid Synthesis and Oxidation as Potential Anticancer Agents in Colorectal Cancer Treatment.脂肪酸合成与氧化抑制剂作为结直肠癌治疗中的潜在抗癌药物
Anticancer Res. 2020 Sep;40(9):4843-4856. doi: 10.21873/anticanres.14487.
9
Fatty acid oxidation inhibitor etomoxir suppresses tumor progression and induces cell cycle arrest via PPARγ-mediated pathway in bladder cancer.脂肪酸氧化抑制剂 etomoxir 通过 PPARγ 介导的途径抑制膀胱癌的肿瘤进展并诱导细胞周期停滞。
Clin Sci (Lond). 2019 Aug 7;133(15):1745-1758. doi: 10.1042/CS20190587. Print 2019 Aug 15.
10
Serum deprivation response functions as a tumor suppressor gene in papillary thyroid cancer.血清剥夺反应在甲状腺乳头状癌中作为一种肿瘤抑制基因发挥作用。
Clin Genet. 2019 Nov;96(5):418-428. doi: 10.1111/cge.13609. Epub 2019 Jul 31.