Department of Geriatric Gastroenterology, Neuroendocrine Tumor Center, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Institute of Neuroendocrine Tumor, Nanjing Medical University, Nanjing, China.
Int J Biol Sci. 2023 Jun 12;19(10):3115-3127. doi: 10.7150/ijbs.85285. eCollection 2023.
Lipid metabolism plays an important role in the occurrence and development of cancer, in particular, digestive system tumors such as colon cancer. Here, we investigated the role of the fatty acid-binding protein 5 () in colorectal cancer (CRC). We observed marked down-regulation of in CRC. Data from functional assays revealed inhibitory effects of on cell proliferation, colony formation, migration, invasion as well as tumor growth . In terms of mechanistic insights, interacted with fatty acid synthase () and activated the ubiquitin proteasome pathway, leading to a decrease in expression and lipid accumulation, moreover, suppressing signaling and facilitating cell autophagy. Orlistat, a inhibitor, exerted anti-cancer effects both and . Furthermore, the upstream RNA demethylase positively regulated expression via an mA-independent mechanism. Overall, our collective findings offer valuable insights into the critical role of the // axis in tumor progression and uncover a potential mechanism linking lipid metabolism to development of CRC, providing novel therapeutic targets for future interventions.
脂质代谢在癌症的发生和发展中起着重要作用，特别是在消化系统肿瘤如结肠癌中。在这里，我们研究了脂肪酸结合蛋白 5（）在结直肠癌（CRC）中的作用。我们观察到在 CRC 中显著下调。功能分析的数据显示，对细胞增殖、集落形成、迁移、侵袭以及肿瘤生长都具有抑制作用。在机制研究方面，与脂肪酸合酶（）相互作用并激活了泛素蛋白酶体途径，导致表达减少和脂质积累，此外，抑制信号和促进细胞自噬。抑制剂奥利司他（）对和都发挥了抗癌作用。此外，上游 RNA 去甲基酶通过非 mA 依赖机制正向调节的表达。总的来说，我们的研究结果提供了有价值的见解，阐明了 // 轴在肿瘤进展中的关键作用，并揭示了脂质代谢与 CRC 发展之间的潜在机制，为未来的干预提供了新的治疗靶点。
