Wenzel Miwa, Aquadro Charles F
Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States.
MicroPubl Biol. 2023 May 25;2023. doi: 10.17912/micropub.biology.000845. eCollection 2023.
The bacterial endosymbiont manipulates reproduction of its arthropod hosts to promote its own maternal vertical transmission. In female , has been shown to genetically interact with three key reproductive genes ( ( ) and , as it rescues the reduced female fertility or fecundity phenotype seen in partial loss-of-function mutants of these genes Here, we show that also partially rescues male fertility in carrying a new, largely sterile allele when in a null genetic background. This finding shows that the molecular mechanism of 's influence on its hosts' reproduction involves interaction with genes in males as well as females, at least in .
细菌内共生体操纵其节肢动物宿主的繁殖，以促进自身的母系垂直传播。在雌性中，已证明它与三个关键生殖基因（（）和）发生遗传相互作用，因为它挽救了这些基因部分功能丧失突变体中出现的雌性生育力或繁殖力降低的表型。在这里，我们表明，当处于 null 遗传背景时，在携带新的、基本不育的等位基因的中，也能部分挽救雄性生育力。这一发现表明，影响其宿主繁殖的分子机制至少在中涉及与雄性和雌性基因的相互作用。
