角质层储库的测量：一种预测载体对体内经皮吸收影响的简单方法。

The measurement of the stratum corneum reservoir: a simple method to predict the influence of vehicles on in vivo percutaneous absorption.

作者信息

Dupuis D, Rougier A, Roguet R, Lotte C

出版信息

Br J Dermatol. 1986 Aug;115(2):233-8. doi: 10.1111/j.1365-2133.1986.tb05723.x.

DOI:10.1111/j.1365-2133.1986.tb05723.x

Abstract

The influence of nine vehicles on in vivo percutaneous absorption of benzoic acid has been studied in the hairless rat. Although the vehicles used were simple in composition, the total amount of benzoic acid which penetrated varied by a factor of 50. A weak relationship was found between penetration of benzoic acid and its maximum solubility in the different vehicles. A linear relationship was demonstrated between the amount of benzoic acid present in the stratum corneum at the end of a 30 min application period and the total amount absorbed over 4 days. We suggest that the influence of a vehicle on the overall absorption of a substance can therefore be predicted by simply measuring the amount present in the stratum corneum at the end of a 30 min application period.

摘要

在无毛大鼠中研究了九种赋形剂对苯甲酸体内经皮吸收的影响。尽管所使用的赋形剂成分简单，但苯甲酸渗透的总量相差50倍。发现苯甲酸的渗透率与其在不同赋形剂中的最大溶解度之间存在微弱关系。在30分钟涂抹期结束时角质层中苯甲酸的含量与4天内吸收的总量之间呈现线性关系。因此，我们认为通过简单测量30分钟涂抹期结束时角质层中存在的量，就可以预测赋形剂对物质整体吸收的影响。