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Implications of family history and polygenic risk scores for causation.

作者信息

Li Shuai, Hopper John L

机构信息

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC 3053, Australia; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC 3168, Australia; Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC 3051, Australia.

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC 3053, Australia.

出版信息

Am J Hum Genet. 2023 Jul 6;110(7):1221-1223. doi: 10.1016/j.ajhg.2023.05.015.

DOI:10.1016/j.ajhg.2023.05.015
PMID:37419094
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10357467/
Abstract
摘要

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Segregation analysis of 17,425 population-based breast cancer families: Evidence for genetic susceptibility and risk prediction.基于人群的 17425 个乳腺癌家系的分离分析：遗传易感性和风险预测的证据。
Am J Hum Genet. 2022 Oct 6;109(10):1777-1788. doi: 10.1016/j.ajhg.2022.09.006.
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Age dependency of the polygenic risk score for colorectal cancer.结直肠癌多基因风险评分的年龄依赖性。
Am J Hum Genet. 2021 Mar 4;108(3):525-526. doi: 10.1016/j.ajhg.2021.02.002.
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Negative Age-Dependence of the Polygenic Risk Score Gradient for Colorectal Cancer.结直肠癌多基因风险评分梯度的负年龄依赖性
Gastroenterology. 2021 May;160(6):2214-2215. doi: 10.1053/j.gastro.2020.09.064. Epub 2020 Dec 30.
5
Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses.通过家系内分析避免孟德尔随机化中的家族性、选择性交配和群体分层偏倚。
Nat Commun. 2020 Jul 14;11(1):3519. doi: 10.1038/s41467-020-17117-4.
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Inference about causation from examination of familial confounding (ICE FALCON): a model for assessing causation analogous to Mendelian randomization.从家族性混杂因素（ICE FALCON）考察中推断因果关系：一种类似于孟德尔随机化的因果评估模型。
Int J Epidemiol. 2020 Aug 1;49(4):1259-1269. doi: 10.1093/ije/dyaa065.
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The Heritability of Breast Cancer among Women in the Nordic Twin Study of Cancer.北欧癌症双胞胎研究中女性乳腺癌的遗传度
Cancer Epidemiol Biomarkers Prev. 2016 Jan;25(1):145-50. doi: 10.1158/1055-9965.EPI-15-0913. Epub 2015 Nov 10.
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Family history, mammographic density, and risk of breast cancer.家族史、乳腺密度与乳腺癌风险。
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Prediction and interaction in complex disease genetics: experience in type 1 diabetes.复杂疾病遗传学中的预测与相互作用：1型糖尿病的经验
PLoS Genet. 2009 Jul;5(7):e1000540. doi: 10.1371/journal.pgen.1000540. Epub 2009 Jul 3.
10
Statistical validation of intermediate endpoints for chronic diseases.慢性病中间终点的统计学验证。
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