两个开关的故事：人类和植物中腺苷-5'-磷酸硫酸激酶的氧化还原调控。
A tale of two switches: Redox regulation of adenosine-5'-phosphosulfate kinase in humans and plants.
机构信息
Department of Biology, Washington University in St. Louis, St. Louis, MO 63130, USA.
Department of Biology, Washington University in St. Louis, St. Louis, MO 63130, USA.
出版信息
Structure. 2023 Jul 6;31(7):757-759. doi: 10.1016/j.str.2023.06.006.
PMID:37419098
Abstract
The sulfate donor 3'-phosphoadenosine-5'-phosphosulfate (PAPS) is a near-universal component of sulfur metabolism. In a report by Zhang et al. in this issue of Structure, X-ray crystal structures of the APS kinase domains from human PAPS synthase reveal dynamic substrate recognition and a regulatory "redox switch" analogous to that previously described only in plant APS kinases.
摘要
硫酸供体 3'-磷酸腺苷-5'-磷酸硫酸（PAPS）是硫代谢的普遍成分。在张等人的报告中，该结构的 X 射线晶体结构揭示了人 PAPS 合酶 APS 激酶结构域的动态底物识别和类似于先前仅在植物 APS 激酶中描述的调节“氧化还原开关”。
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