Mathé A A, Eberhard G, Sääf J, Wetterberg L
Biol Psychiatry. 1986 Sep;21(11):1024-30. doi: 10.1016/0006-3223(86)90283-0.
Blood samples were obtained from 18 twin pairs, and the major prostaglandin E2 (PGE2) plasma metabolite 15-keto-13,14-dihydro-PGE2 was measured by RIA after its conversion to 11-deoxy-15-keto-13,14-dihydro-11 beta,16 xi-cyclo-PGE2. Significant positive correlations were found in all the twin pairs, in 11 pairs diagnosed as DSM-III schizophrenic disorder and schizoid/schizotypal personality disorder, and in the 5 nonschizophrenic pairs. These results indicate that synthesis of prostaglandins (PGs) is in part genetically determined. With regard to absolute PGE2 metabolite levels, the data did not support the hypothesis of increased PGE2 in schizophrenia. Thus, seven of eight schizophrenic probands had lower metabolite concentrations than their healthy twin siblings, and in one pair they were similar. Furthermore, schizophrenic probands and their healthy sibling controls, taken as a group, had lower PGE2 metabolite levels than the group comprised of affective disorder probands and their respective controls. These findings raise the possibility that a change in PGE2 may be associated with schizophrenic and also possibly with affective disorders.
从18对双胞胎中采集血样，主要前列腺素E2（PGE2）的血浆代谢物15-酮-13,14-二氢-PGE2在转化为11-脱氧-15-酮-13,14-二氢-11β,16ξ-环-PGE2后通过放射免疫分析法进行测定。在所有双胞胎对中、在11对被诊断为DSM-III精神分裂症障碍和类精神分裂症/分裂型人格障碍的双胞胎对中以及在5对非精神分裂症双胞胎对中均发现显著的正相关。这些结果表明前列腺素（PGs）的合成部分由基因决定。关于PGE2代谢物的绝对水平，数据不支持精神分裂症中PGE2增加的假设。因此，8名精神分裂症先证者中有7名的代谢物浓度低于其健康的双胞胎兄弟姐妹，在一对双胞胎中二者相似。此外，作为一个整体，精神分裂症先证者及其健康的同胞对照的PGE2代谢物水平低于由情感障碍先证者及其各自对照组成的组。这些发现增加了PGE2的变化可能与精神分裂症以及可能与情感障碍相关的可能性。
