克罗恩病中的口服卡介苗疫苗
Oral BCG vaccine in Crohn's disease.
作者信息
Burnham W R, Lennard-Jones J E, Hecketsweiler P, Colin R, Geffroy Y
出版信息
Gut. 1979 Mar;20(3):229-33. doi: 10.1136/gut.20.3.229.
Abstract
In a randomised double-blind trial over one year oral BCG has been compared with a control preparation in the treatment of chronic Crohn's disease. Overall assessment scores deteriorated in nine of 22 patients taking BCG, and 11 of 26 in the control group (P = 0.25); this deterioration was great enough to be regarded as a clinical relapse in three patients taking BCG and in seven taking the control preparation (P greater than 0.1). No significant benefit from oral BCG treatment has been demonstrated.
摘要
在一项为期一年的随机双盲试验中，对口服卡介苗与一种对照制剂治疗慢性克罗恩病的效果进行了比较。服用卡介苗的22名患者中有9名总体评估得分恶化，而对照组26名患者中有11名出现这种情况（P = 0.25）；这种恶化严重到足以被视为3名服用卡介苗的患者和7名服用对照制剂的患者出现临床复发（P>0.1）。口服卡介苗治疗未显示出显著益处。
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1
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Gastroenterology. 1974 May;66(5):916-22.
2
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J Natl Cancer Inst. 1973 Nov;51(5):1655-67. doi: 10.1093/jnci/51.5.1655.
3
Controlled trial of azathioprine in Crohn's disease.
Lancet. 1971 Dec 11;2(7737):1273-6. doi: 10.1016/s0140-6736(71)90598-8.
4
Controlled trial of azathioprine in Crohn's disease.
Lancet. 1971 Oct 30;2(7731):944-7. doi: 10.1016/s0140-6736(71)90268-6.
5
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6
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7
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8
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9
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