要素饮食作为急性克罗恩病的主要治疗方法：一项对照试验。
Elemental diet as primary treatment of acute Crohn's disease: a controlled trial.
作者信息
O'Moráin C, Segal A W, Levi A J
出版信息
Br Med J (Clin Res Ed). 1984 Jun 23;288(6434):1859-62. doi: 10.1136/bmj.288.6434.1859.
Abstract
Acute exacerbations of Crohn's disease are usually treated with prednisolone or potentially more toxic immunosuppressive drugs or by surgery. In pilot studies replacing the normal diet by a protein free elemental diet also induced remission. A controlled trial was therefore conducted in which 21 patients acutely ill with exacerbations of Crohn's disease were randomised to receive either prednisolone 0.75 mg/kg/day or an elemental diet (Vivonex) for four weeks. Assessment at four and 12 weeks showed that the patients treated with the elemental diet had improved as much as and by some criteria more than the steroid treated group. Elemental diet is a safe and effective treatment for acute Crohn's disease.
摘要
克罗恩病的急性加重通常用泼尼松龙或毒性可能更大的免疫抑制药物治疗，或通过手术治疗。在试点研究中，用无蛋白要素饮食替代正常饮食也可诱导缓解。因此进行了一项对照试验，将21例因克罗恩病急性加重而病情严重的患者随机分为两组，一组接受0.75毫克/千克/天的泼尼松龙治疗，另一组接受要素饮食（Vivonex）治疗，为期四周。四周和十二周时的评估表明，接受要素饮食治疗的患者改善程度与接受类固醇治疗的组相同，且在某些标准下改善程度更大。要素饮食是治疗克罗恩病急性发作的一种安全有效的方法。
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