Collegium Medicum im. dr Władysława Biegańskiego, Jan Długosz University in Częstochowa, 13/15 Armii Krajowej St., 42-200 Częstochowa, Poland.
Faculty of Medical and Social Sciences, Warsaw Medical Academy of Applied Sciences, 8 Rydygiera St., 01-793 Warszawa, Poland.
Sensors (Basel). 2023 Jun 14;23(12):5582. doi: 10.3390/s23125582.
Leg ulcers are a very serious worldwide medical problem. When the ulcer is extensive and deep the prognosis is usually unfavorable. The treatment requires comprehensive solutions that take into account modern specialized medical dressings, and more and more often, selected methods in the field of physical medicine. The study included 30 patients (13 women-43.4% and 17 men-56.6%) with chronic arterial ulcers of the lower limbs. The mean age of the treated patients was 65.63 ± 8.77 years. Patients were randomly assigned to two study groups. In group 1 (16 patients), specialist ATRAUMAN Ag medical dressings and local hyperbaric oxygen therapy treatments were used. In group 2 (14 patients), only specialized ATRAUMAN Ag dressings were used. The treatment was carried out for 4 weeks. The progress of healing ulcers was assessed by using the planimetric method, while the intensity of pain ailments was assessed by the visual analog VAS scale. In both study groups, a statistically significant reduction in the mean surface area of the treated ulcers was obtained, respectively, from 8.53 ± 1.71 cm to 5.55 ± 1.11 cm in group 1 ( < 0.001) and 8.43 ± 1.51 cm to 6.28 ± 1.13 cm in group 2 ( < 0.001). There was also a statistically significant reduction in the intensity of pain ailments, respectively: 7.93 ± 0.68 points to 5.00 ± 0.63 points in group 1 ( < 0.001) and 8.00 ± 0.67 points to 5.64 ± 0.49 points in group 2 ( < 0.001). The percentage change in ulcer area from baseline in group 1 was 34.6 ± 8.47% and was statistically significantly greater than in group 2 (25.23 ± 6.01%) ( = 0.003). In turn, the percentage assessment of the pain intensity assessed in the VAS scale in group 1 was 36.97 ± 6.36% and was statistically significantly higher compared to group 2 (29.34 ± 4.77%) ( = 0.002). The addition of local hyperbaric oxygen therapy treatments as a supplement to the therapy with the use of specialized medical dressings improves the effectiveness the arterial ulcers treatment of the lower limbs in terms of reducing the ulceration area and reducing pain ailments.
下肢慢性动脉溃疡是一种非常严重的全球性医学问题。当溃疡广泛且较深时，预后通常不佳。治疗需要综合解决方案，考虑到现代专业医疗敷料，以及越来越多的物理医学领域的选择方法。
本研究纳入了 30 例下肢慢性动脉溃疡患者（13 名女性，占 43.4%，17 名男性，占 56.6%）。治疗患者的平均年龄为 65.63 ± 8.77 岁。患者被随机分配到两个研究组。在第 1 组（16 例患者）中，使用了 ATRAUMAN Ag 医疗敷料和局部高压氧治疗。在第 2 组（14 例患者）中，仅使用了专门的 ATRAUMAN Ag 敷料。治疗持续 4 周。通过平面测量法评估溃疡愈合的进展，通过视觉模拟 VAS 量表评估疼痛的强度。在两个研究组中，治疗后溃疡的平均表面积均显著减少，第 1 组从 8.53 ± 1.71 cm 减少至 5.55 ± 1.11 cm（<0.001），第 2 组从 8.43 ± 1.51 cm 减少至 6.28 ± 1.13 cm（<0.001）。疼痛强度也显著降低，第 1 组从 7.93 ± 0.68 分降至 5.00 ± 0.63 分（<0.001），第 2 组从 8.00 ± 0.67 分降至 5.64 ± 0.49 分（<0.001）。第 1 组的溃疡面积从基线的变化百分比为 34.6 ± 8.47%，明显大于第 2 组（25.23 ± 6.01%）（=0.003）。相反，第 1 组在 VAS 量表中评估的疼痛强度百分比为 36.97 ± 6.36%，明显高于第 2 组（29.34 ± 4.77%）（=0.002）。将局部高压氧治疗作为专门医疗敷料治疗的补充，可以改善下肢动脉溃疡的治疗效果，在减少溃疡面积和减轻疼痛方面。
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