van Leeuwen F W, Caffé R, van der Sluis P J, Sluiter A A, van der Woude T P, Seidah N G, Chrétien M
Brain Res. 1986 Jul 30;379(1):171-5. doi: 10.1016/0006-8993(86)90272-6.
Vasopressin (VP) is synthesized as propressophysin, containing also neurophysin (NP) and C-terminal glycopeptide (CPP), within the hypothalamo-neurohypophyseal system (HNS). Recently, VP and NP-immunoreactive cells were demonstrated in other rat brain nuclei. Here we report CPP immunoreactivity in perikarya in these nuclei. Within the homozygous Brattleboro rat, known to be deficient in neuronal VP production, no CPP immunoreactivity was seen in these nuclei. However, intense VP and CPP immunoreactivity was present in solitary cells (52.2 +/- 3.3 per rat) and fibres within the HNS.
血管加压素（VP）在下丘脑-神经垂体系统（HNS）中作为血管加压素原合成，还包含神经垂体素（NP）和C末端糖肽（CPP）。最近，在大鼠的其他脑核中发现了VP和NP免疫反应性细胞。在此，我们报告这些核内神经元胞体中的CPP免疫反应性。在已知神经元VP生成缺陷的纯合子布拉特洛维大鼠中，这些核内未观察到CPP免疫反应性。然而，HNS内的单个细胞（每只大鼠52.2±3.3个）和纤维中存在强烈的VP和CPP免疫反应性。
