Lu C L, Cantin M, Seidah N G, Chrétien M
Histochemistry. 1982;75(3):319-26. doi: 10.1007/BF00496735.
The distribution pattern of CPP-containing neurons and fibers in the human pituitary and hypothalamus was studied with a specific antiserum to human CPP and the unlabeled antibody technique. Immunoreactive CPP was found in the magnocellular neurons of the supraoptic nucleus (SON), the paraventricular nucleus (PVN) and in neurons scattered in the supraoptic hypophyseal tract. CPP-containing parvocellular neurons were found in the suprachiasmatic nucleus (SCN). The CPP-containing fibers from the magnocellular neurons formed a tract coursing through the median eminence and the pituitary stalk to the posterior lobe of the hypophysis. In contrast, no such fibers from the SCN projected to SON, PVN and the median eminence. This pattern is identical to that of vasopressin and its associated neurophysin-containing neurons and fibers and strongly supports the concept that CPP is a part of the common precursor for vasopressin and neurophysin II. The biological importance of human CPP other than being a precursor fragment remains to be elucidated.
采用抗人促肾上腺皮质激素释放肽（CPP）特异性抗血清及非标记抗体技术，研究了含CPP的神经元和纤维在人垂体和下丘脑的分布模式。在视上核（SON）、室旁核（PVN）的大细胞神经元以及散在于视上垂体束中的神经元中发现了免疫反应性CPP。在视交叉上核（SCN）中发现了含CPP的小细胞神经元。来自大细胞神经元的含CPP纤维形成一条束，穿过正中隆起和垂体柄至垂体后叶。相比之下，SCN中没有这样的纤维投射到SON、PVN和正中隆起。这种模式与血管加压素及其相关的含神经垂体素的神经元和纤维的模式相同，并有力地支持了CPP是血管加压素和神经垂体素II共同前体一部分的概念。除作为前体片段外，人CPP的生物学重要性仍有待阐明。
