Dental Health Department, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Biomedical Technology Department, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Photodiagnosis Photodyn Ther. 2023 Sep;43:103690. doi: 10.1016/j.pdpdt.2023.103690. Epub 2023 Jul 6.
To evaluate the clinical, radiographic, immune modulatory biomarkers and quality of life with the application of photodynamic therapy (PDT) as an adjunctive treatment to dental scaling and root planing (SRP) in patients with chronic periodontitis and Parkinson's disease.
Individuals who had a confirmed diagnosis of stage III periodontitis and stage 4 Parkinson's disease according to Hoehn and Yahr scale were involved in this study. The participants were divided into two groups: Group SRP (n = 25) received traditional dental scaling procedure including full-mouth debridement and disinfection, and Group PDT + SRP (n = 25) received both traditional cleaning procedures along with adjunctive chloro‑aluminum phthalocyanine (CAPC) gel (0.005% concentration) mediated PDT. CAPC photosensitizer was activated using a diode laser (wavelength=640 nm, energy=4 J, 150 mW power, and overall power density of 300 J/cm) for 60 s. The study measured clinical parameters such as plaque score (PI), bleeding on probing (BOP), probing depth (PD), clinical attachment loss (CAL), and radiographic alveolar bone loss (ABL). Proinflammatory cytokine levels such as interleukin (IL)-6 and tumor necrosis factor alpha (TNF-α) and oral health related quality of life were also assessed.
The mean age of patients in Group SRP was 73.3 years, while the mean age in Group PDT + SRP was 71.6 years. The PDT + SRP group showed a significant reduction in all clinical parameters at 6 and 12 months compared to the SRP group alone (p < 0.05). IL-6 and TNF-α levels were significantly reduced in the PDT + SRP group at 6 months compared to the SRP group alone (p < 0.05). However, at 12 months, both groups showed comparable TNF-α levels. The results showed that Group PDT + SRP had significantly lower OHIP scores compared to Group SRP, with a mean difference of 4.55 (95% confidence interval [CI]: 1.98 to 7.12) (p < 0.01).
Combined SRP with PDT showed significant improvement compared to SRP alone in terms of clinical parameters, cytokine levels, and oral health-related quality of life in individuals diagnosed with stage III periodontitis associated with Parkinson's disease.
评估光动力疗法（PDT）作为慢性牙周炎和帕金森病患者牙周基础治疗（SRP）辅助治疗的临床、放射学、免疫调节生物标志物和生活质量。
本研究纳入了根据 Hoehn 和 Yahr 量表确诊为 III 期牙周炎和 4 期帕金森病的个体。参与者分为两组：SRP 组（n=25）接受传统的牙科洁治程序，包括全口清创和消毒，PDT+SRP 组（n=25）接受传统的清洁程序和辅助氯-铝酞菁（CAPC）凝胶（0.005%浓度）介导的 PDT。CAPC 光敏剂使用二极管激光（波长=640nm，能量=4J，150mW 功率，总功率密度 300J/cm）激活 60s。研究测量了临床参数，如菌斑指数（PI）、探诊出血（BOP）、探诊深度（PD）、临床附着丧失（CAL）和放射状牙槽骨丧失（ABL）。还评估了促炎细胞因子水平，如白细胞介素（IL）-6 和肿瘤坏死因子-α（TNF-α）和口腔健康相关生活质量。
SRP 组患者的平均年龄为 73.3 岁，而 PDT+SRP 组的平均年龄为 71.6 岁。与单独 SRP 组相比，PDT+SRP 组在 6 个月和 12 个月时所有临床参数均显著降低（p<0.05）。与单独 SRP 组相比，PDT+SRP 组在 6 个月时 IL-6 和 TNF-α水平显著降低（p<0.05）。然而，在 12 个月时，两组的 TNF-α水平相当。结果表明，与 SRP 组相比，PDT+SRP 组的 OHIP 评分明显更低，平均差异为 4.55（95%置信区间[CI]：1.98 至 7.12）（p<0.01）。
与单独 SRP 相比，SRP 联合 PDT 在 III 期牙周炎合并帕金森病患者的临床参数、细胞因子水平和口腔健康相关生活质量方面有显著改善。
