多发性硬化症中的脑诱发电位

Cerebral evoked potentials in multiple sclerosis.

作者信息

Javidan M, McLean D R, Warren K G

出版信息

Can J Neurol Sci. 1986 Aug;13(3):240-4. doi: 10.1017/s0317167100036349.

Abstract

Multimodal evoked potentials were analyzed from 58 possible, 62 probable and 100 definite (total 220) multiple sclerosis (MS) patients. Visual evoked potentials (VEP) were most frequently abnormal yielding 39%, 69%, 84% in the three diagnostic groups respectively. Median nerve sensory evoked potentials (SEP) yielded abnormalities in 26%, 65%, 79% respectively. Brainstem auditory evoked responses (BAER) were abnormal in 17%, 39%, 66% respectively. We measured the combined amplitude (CA) of waves III, IV, V in the BAER of these patients as an objective measure of amplitude asymmetry. The CA was considered abnormal if it was 1SD below the lowest CA value in the control group. The CA was abnormal in 9.2% of BAER with normal central conduction time. The BAER diagnostic yield in MS patients increased 11% by using CA analysis.

摘要

对58例可能的、62例很可能的以及100例确诊的（共220例）多发性硬化症（MS）患者进行了多模式诱发电位分析。视觉诱发电位（VEP）异常最为常见，在三个诊断组中分别为39%、69%、84%。正中神经感觉诱发电位（SEP）异常率分别为26%、65%、79%。脑干听觉诱发电位（BAER）异常率分别为17%、39%、66%。我们测量了这些患者BAER中III、IV、V波的复合波幅（CA），作为波幅不对称性的客观指标。如果CA低于对照组最低CA值1个标准差，则认为CA异常。在中枢传导时间正常的BAER中，9.2%的CA异常。通过使用CA分析，MS患者的BAER诊断率提高了11%。